Preliminary Study Of Umbilical Cord Blood Stem Cell Transplantation In Decompensated Liver Cirrhosis

Objective:Our study aimed to investigate the efficacy and safety of umbilical cord blood stem cell transplantation in decompensated liver cirrhosis.Methods:43patients with decompensated liver cirrhosis were selected in the study. Based on medicine therapy, all patients underwent umbilical cord blood stem cell transplantation ranged from one to four times. Clinical symptoms、levels of ALB、ALT、AST、TBIL、PT、 Fib、AFP、Child-pugh and safety were observed at baseline and1、2、24week after transplantation.Results:At2week after transplantation,23patients (53.5%) felt abdominal distension released,20patients (46.5%) felt anorexia released,19patients (44.2%) felt fatigue released. At24week,25patients (89.3%) felt abdominal distension released,22patients (78.6%) felt anorexia released,20patients (71.4%) felt fatigue released. The change of clinical symptoms was different at2week compared with that at24week (P<0.05). ALB level was higher than that in baseline at1、2、24week after transplantation and the level was different at2and24week (P<0.05).ALT level was lower than that in baseline at1、2and24week after transplantation (P<0.05). AST level was lower than that in baseline at1、2、24week after transplantation and the level was different at1and2week (P<0.05). TBIL level was lower than that in baseline at1、2、24week after transplantation and the level was different at1and24week (P<0.05). PT level was lower than that in baseline at1、2、24week after transplantation without significant difference after transplantation (P>0.05). Fib level was lower than that in baseline at1、2week after transplantation (P<0.05) and reached the baseline at24week. AFP level was much higher than that in baseline at1week after transplantation (P<0.01). The numbers of Child-pugh C reduced and Child-pugh B increased at2week after transplantation. The numbers of Child-pugh A increased at24week. Child-pugh improved at24week compared with baseline and that at2week (P<0.05) There were no obvious adverse reactions after umbilical cord blood stem cell transplantation in all patients.Conclusions:Umbilical cord blood stem cell transplantation could improve clinical symptoms、ALB、ALT、AST、TBIL and Child-pugh in patients with decompensated liver cirrhosis. Umbilical cord blood stem cells transplantation which was safe was expected to become another new treatment for decompensated liver cirrhosis.