The Value Of Serum Cystatin C And Beta-trace Protein In Early Indicators Of Contrast Induced Nephropathy

ObjectiveTo study clinical value of cystatin C (Cys C) and beta-trace protein(BTP) in earlyindicators of contrast induced nephropathy (CIN).MethodsTotal100patients (66men and34women, mean±SD age,68.72±8.16years）aftercoronary arteriography(CAG) or percutaneous coronary intervention (PCI) wereenrolled in this study from June2011to april2012. Age, sex, weight, risk factor ofcoronary heart disease, medicines, dosage of contrast medium, transfusion volume, et al.The BTP, Cys C, serum creatinine (Scr)，and estimated glomerular filtration rate (eGFR)were measured in24h before angiography. Scr was measured24h，48h after theangiography，respectively. The selected patients were divided into CIN group andnon-CIN group according to changes in serum creatinine levels with48h after CAG or PCI. Compared materials between the groups with and without CIN, and then weanalyzed the value of serum CysC and BTP in early indicators of contrast inducednephropathy by Spearman correlation, receiver operating characteristic (ROC) curveand Binary logistic regression analysis.Results①.The prevalence of CIN was12.0%(12/100).②.There was significant difference between CIN group and non-CIN group in BTP, CysC, Scr and eGFR (P<0.05).③.Spearman correlation was to analyze the association of CIN with the variables. CINwas positively correlated with CysC (r=0.357，P<0.01), BTP (r=0.309，P<0.01), Scr(r=0.238，P=0.017), and negatively correlated with eGFR (r=-0.246，P=0.014). Therewas no correlation with age, DM, HBP, statin, CCB, ACEI/ARB,dosage of contrastmedium and transfusion volume(P>0.05, respectively).④.To set a cutoff level of serum CysC、BTP at the occurrence of CIN, a receiveroperating characteristic (ROC) curve, the sensitivity and specificity were calculated.When the cutoff levels of serum CysC and BTP were set at>1.29mg/L and>3.91μg/l,the sensitivity were83.3%and75%, and the specificity were83%and78.4%,respectively.⑤.Whether contrast nephropathy as dependent variable, binary logistic regressionanalysis demonstrated that baseline serum cystatin C independently predicted CIN(odds ratio [OR],5.192;95%confidence interval [CI]1.045-25.897; P=045).ConclusionThere was no significant clinical value of β-trace Protein in early indicators of CIN.Cystatin C was useful for predicting the occurrence of CIN.