Study On Chemical Constituents Of Dai Medicine Bin Hao And Voacanga Africana Stapf

This dissertation is composed of four chapters. The first chapter and thesecond chapter reported the chemical constituents from Clerodendrum philippinumSchau. var. simplex C. Y. Wu et R. C. Fang and Voacanga africana Stapf and theirpharmacological activities. The third chapter summarizes the study on chemicalconstituents and pharmacological activities of the genus Clerodendrum. The fourthchapter carries on the summary to the research on the chemical constituents andpharmacological activities of the genus Voacanga.32compounds were isolated from to plants mentioned above in totaland30compounds were identified by extensive spectroscopic analysis.Chapter1Chemical constituents from the stem bark of Clerodendrum philippinumSchau. var. simplex C. Y. Wu et R. C. FangFrom the Dai medicine bin Hao (Clerodendrum philippinum Schau. var.simplex C. Y. Wu et R. C. Fang)15compounds were isolated from the ethanol extract,were identified as Octacosanoate taraxerol (1), Taraxerol (2), Myricadiol (3), Friedelin(4), quinovic acid3-β-D-glucopyranoside (5),Clerosterol glucoside(6),22-Dehydro--clerosterol (7)4,4-dimethyl-cholesta-22,24-dien-5-ol (8), uncinatone (9),11,12,14-tr--ihydroxyabieta-8,11,13-trien-7-one (10), clerodenone A (11),9-hydroxytridecyl do--cosanoate (12), tetracosanoic acid (13), indolyl-3-carboxylic acid (14) and elerodeno--side A (15). Compounds1-5of three terpene (glycoside),6-8for steroid (glycoside),9-10two terpenes,11for a two monomer,12-13as long chain fatty acid,14indoleacetic acid,15for benzene hormone. Anti-inflammatory activity screeningshowed that the ethyl acetate extraction, the extract and compound9,15on theformation of NO have certain inhibition. All the compounds were isolated from thisplant, compound1is a new compound.Chapter2Chemical constituents from the Voacanga africana Stapf 17compounds have been isolated from the ethanol extract of non-alkaloidpart of Voacanga africana Stapf were identified asβ-amyrin acetate(16),3-hydroxy-12-ta--raxasten-28-oic-acid(17)，3β,28-dihydroxyurs-12-en-27-oic acid(18),Olean--olic acid (19),isolupenyl acetate(20),daucosterol(21),Stigmasterol(22),β-sitosterol(23),Dissob-atylePhthalate(24),3-methoxy-4-hydroxybenzaldehyde(25),1-Decanethiol(26)wherein the compound (16) for acetic ester, compound17-25for steroid(glycos--ide),Compound26-27for ceramides，compound28is a lipid, compound29is abenzoic acid, compound30is a thiol removal compounds22and23, all thecompounds were isolated from this plant for the first time.Chapter3Review: Advances in chemical constituents of Clerodendrum plantsIn this chapter, on the basis of previous research in recent years is reviewed.Progress in domestic for the study of chemical constituents and biological activities ofscholars of Clerodendrum Verbenaceae plants of the genus. The results show that thechemical composition and structure of diverse plant genera in Clerodendrum, terpenes,sterols, phenylpropanoid glycosides, phenylethyl alcohol (glycoside), lignans andvolatile compounds; chemical constituents of the genus biological activity is mainlyreflected in the anti-inflammatory, analgesic, anti tumor, the treatment of malaria.Chapter4Review: Advances in chemical constituents of Voacanga plantsIn this chapter, on the basis of previous research in recent years is reviewed.Progress in domestic for the study of chemical constituents and biological activities ofscholars of the Apocynaceae Voacanga plants of the genus. The results showed thatpotato fruit of diversity, plant chemical composition and structure to alkaloids, sterols,triterpene; chemical constituents of this genus are mainly embodied in the biologicalactivity of anti-inflammatory, anti-addiction.