| Objective: To explore characteristics and rules of the dosage of clinical prescriptionby master doctors of Chinese Medicine. Methods: To use traditional documentary methodand Prescription Metrology to compare and analyze the clinical prescriptions by masterdoctors of Chinese medicine with other doctors, based on different doctors in differentareas, schools and dynasties, to show regular usage of clinical prescription by masterdoctors of Chinese Medicine. Results:(1) The number of average per square drug bymaster doctors of Chinese medicine is12.61, the total prescription for mean value is12.64, the dosage of the standard deviation is4.87, the average single medicine mean is1.02, single drug standard deviation number is0.48, the largest single dosage were numberis1.88, and the smallest single dosage number is0.45. The dosage of clinical prescriptionby Zhang Qi, Ren Jixue, Guo Ziguang, and Qiu peiran is larger; the dosage of clinicalprescription by Ban Xiuwen, Fang Heqian, He Ren and Zhang Canjia is smaller. Themaximum total treatment mean is19.43by Zhang Qi; the minimum amount of totaltreatment mean is7.9by He Ren and6.82by Ban Xiuwen; the maximum total standarddeviation is Ren Ji-xue, and the minimum is Fang Heqian; The maximum mean of thesingle-agent is1.44by Ren Ji-xue and1.44by Guo Ziguang, and the minimum is0.69byBan Xiuwen. The maximum Single-dose standard deviation of the mean is0.86by RenJi-xue, the minimum is0.23by Fang Heqian. The Maximum single dose mean is by RenJi-xue，the minimum is by Fang Heqian. The minimum single dose mean is by GuoZiguang, the minimum is by Zhang Canjia. In the analysis of national medical mastercomprehensive clustering, Zhang Qiju as a class, He Ren, Zhang Canjia can be clusteredinto one subgroup and Zhang Jingren, Zhou Zhongying, Fang Heqian Lu Zhengzhi andYan Dexin can be divided into one group, Li Zhenhua, Tang Youzhi, Guo Ziguang, LiJiren and Qiu peiran can be clustered into one group.(2) According to the doctors practiced in different areas, six indicators of master doctors of Chinese medicine innortheast are larger than doctors in other areas, while indicators of the doctors in centralregion and eastern region are similar. On analysis of variance in Master doctors of Chinesemedicine, master of traditional Chinese medicine in prescription for total standarddeviation of mean, standard deviation, single drug were the largest single dosage werenumber is P<0.05; the difference between them has statistical significance, the northeastregion and North China region, central region difference, East China master doctors ofChinese medicine, and other indexes had no statistical significance. On analysis ofcomprehensive index, master doctors of Chinese medicine in northeast and southwest canbe classified into one group, doctors from the middle region and the eastern region can bedivided into a subgroup, and doctors in middle region, eastern region and North China canbe clustered into one big group.(3) According to different shools classification, it isindicated that the largest usage of dosage of clinical prescription is Xin’an School; thesmallest one is Menghe School. The indexes of each school showed no significantdifference (P>0.05), and it shows that there is no significant difference in amount ofdosage use between different shools;but The indexes of classical prescription and noclassical prescription master doctors of Chinese medicine are similar.(4) To comparemaster doctors of Chinese medicine with common doctors, the total prescription of drug(17.04) prescribed by common doctor are larger than famous doctors. The totalprescription of drug prescribed by common doctor in the early Qing Dynasty (2.94) is thesmallest one, master doctors of Chinese medicine (12.64), modern doctors (9.9) andcontemporary doctors(8.15) are similar in the total prescription of drug. Other indicatorsalso show that common doctors are the largest ones, and minimum in early Qing Dynasty.It shows that the common doctors usage of clinical prescription is the largest and the usageis the smallest in early Qing Dynasty. The prescription of dosage given by masters oftraditional Chinese medicine and modern doctors and contemporary doctors is similar;analysis of variance of prescription for total and minimum single dosage were P<0.01,values in the six index, the index values were not significantly different, there weresignificant differences in mean in dosage on Master doctors of Chinese medicine and inearly Qing Dynasty, Qing Dynasty, late Qing Dynasty, modern medicine, generalphysicians, no significant difference and the neoteric doctors before, Ming; in the smallestsingle dose mean Master doctors of Chinese medicine and in early Qing Dynasty, QingDynasty, late Qing Dynasty, modern medicine, general medicine A significant difference,no statistical difference with modern medicine and Ming before doctors.(5) By clustering analysis between master doctors and common doctors, it is found that the master doctorsof Chinese medicine and modern medicine can be divided into one group, and commondoctors are another group. Doctors before Ming Dynasty, in Middle age of Qing Dynasty,in Late age of Qing Dynasty and modern age are one group, and early age of Qing dynastyis one group. Conclusion:(1) The dosage of clinical prescription by master doctors ofChinese Medicine is moderate, flexible and not perverse.(2) The dosage of clinicalprescription by master doctors of Chinese Medicine is related to the area, and the doctorsfrom northeast used the largest amount of dosage. And the amount of dosage is alsorelated to department and frequency of the medicine.(3) Medicine dosage since in earlyQing Dynasty so far, there is a trend gradually, The dosage of clinical prescription bymaster doctors of Chinese Medicine is closely related to modern doctors, and it showsthey have the clear inheritance relationship.(4) Compared with the master doctors ofChinese medicine, The dosage of clinical prescription by common doctors is not stableand has no definite rules.(5)master doctors of Chinese Medicine inherit previousdoctors’ ideas and experiences on dosage of clinical prescription and they also have theinnovation and development in their practice. We should learn from the experience ofmaster doctors of Chinese Medicine. |
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