Therapy Efficacy Of Tiotropium Combined Salmeterol/Fluticasone In Patients With Chronic Obstructive Pulmonary Disease(DOPD)

Objective: The propose of this study was to explore the therapy efficacy oftiotropium associate with salmeterol/fluticasone in patients with severely or extremelychronic obstructive pulmonary disease(COPD)．Methods：We conducted a prospectivestudys of50patients with severely or extremely COPD,which were randomly divided intoexperimental group (25cases) and control group (25cases).All patients were givenconventional oxygen,anti-infection,cough relieving,eliminate sputum,and asthma control(intravenous drip Doxofylline) treatment.Tiotropium and salmeterol/fluticasone inhalationwere used in test group.The control group were used salmeterol/fluticasone instead.Testtheir pulmonary function,arterial blood gases,and MRC.before and after six month forpersistent therapy.Results:Before treatment, the two groups of lung function、arterialblood gas and MRC had no significant difference.After treatment for six month,the twogroups of lung function and arterial blood gas had great improve than before (P<0.01).The forced vital capacity (FVC),one second forced expiratory volume (FEV1),firstsecond forced expiratory volume accounted for the predicted value (FEV1%Pred),arterialoxygen pressure (PaO2),arterial carbon dioxide partial pressure (PaCO2),MRC.group werebetter than control group’s (P<0.05).Conclusion:Tiotropium associate with salmeterol/fluticasone were better than salmeterol/fluticasone alone in improving pulmonaryfunction,arterial blood gas and MRC in patients with severe COPD.