Synthesis Of Several Nanomaterials And Their Applications In Drug Delivery

Nanomaterials have played a propitious role in the noninvasive detection andtreatment of tumors because of their unique characteristics inherent to the nanoscale.The development of new nanomaterials for the diagnosis and/or treatment of differentdiseases has been receiving greater attention in recent years and has now become animportant field in medical research. Dedicated nanomaterials can be used to monitorthe progress of a therapy or disease, to determine the blood type of patients requiringtransfusion, or for tissue typing when a transplant is required. Concerning these, sev-eral kinds of nano drug carriers meeting the above requirements have been prepared.The main content of this thesis is as following:（1） Synthesis of pH response ACC/CaIP₆hollow nanomaterial and their applica-tions in drug deliveryIn this part, a novel pH-responsive drug-carrier based on hollow hybrid nano-spheres composed of inorganic amorphous calcium carbonate （ACC） and Ca（II）-IP6compound （CaIP₆） has been developed. Doxorubicin （DOX）, an anticancer drug, hasbeen selected as the loading drug and their pH-controlled release from hollowACC/CaIP₆nanospheres in the endo/lysosomes of cervical cancer cell line （HeLa）cells has been investigated. It turns out that the loading amount of DOX is up to1700mg g-1hollow nanospheres. Most importantly, nearly100%of the DOX can be effec-tively released after24h at body temperature when the pH is4.3. The ACC/CaIP₆nanospheres are biocompatible. In vitro cytotoxicity results show that the toxicity ofDOX-ACC/CaIP₆nanospheres is much lower than that of free DOX. In vivo tumorreduction experiment results indicate that the DOX-ACC/CaIP₆nanospheres are moreefficacious than the free DOX. Because of their high loading amount and controlledrelease in acidic microenviroments, it would be an ideal drug-carrier for potential ap-plications in targeted cancer therapy.（2） Synthesis, characterization of CaCO₃@C nanomaterial and their applicationsin Drug DeliveryIn this chapter, stable ACC/PDA nanocomposite materials coated with dopaminehave been prepared and the effect of the processing conditions on the morphologywas investigated. After treating at different temperature, carbon coated calcium oxidecomposites were obtained. Then the carbon coated calcium oxide composites wereencapsulated with drugs （DOX）. In the presence of carbon dioxide, the calcium oxidechaned into calcium carbonate and thus the drug encapsulation was realized. Makinguse of the characteristics of the calcium carbonate dissolved in acid conditions, drugrelease was realized.（3） Synthesis of rattle-type silica and their applications in biomedicineRattle-type silica nanomaterial with diameters of about100nanometers was syn- thesized using a hydrothermal method for the first time. It turns out that the producthas high encapsulation quantity and good biocompatibility. It is worth mentioning thatboth DOX and FITC can be loaded into the rattle-type silica. Both treatment of cancercell and biological tracer can be realized in this process.（4） In this work, novel cadmium sulfde （CdS） hollow hemispheres were suc-cessfully prepared via an oxalic acid-assisted solvothermal route the first time. Theas-prepared products were characterized by X-ray powder diffraction （XRD）, scan-ning electronic microscope （SEM） and transmission electron microscopy （TEM）. Re-sults show that the morphologies of the products are dependent on the reaction timeand temperature. The optical properties and possible formation process for the CdShollow hemisphere were investigated. The drug carry properties were also investigat-ed.