The Relationship Of C Reactive Protein,Homocysteine And Left Atrial Dimension With Artial Fibrilation

AimsTo investigate the levels of homosysteine (Hey) and high sensitive C reactive protein (hsCRP) in patients with atiral fibrillation (AF), and to explore their roles in the development of atiral fibrillation.Methods148patients with atrial fibrillation and30outpatients in sinus rhythm who were underwent routine physical examination were enrolled in test group and control group respectively. Test group was divided into three subgroups,(paroxysmal AF, persistent AF, permanent AF). The differences of left atrial dimension (LAD), left ventricular ejection fraction (LVEF), the level of CRP, Hcy between test group and control group, as well as paroxysmal AF, persistent AF, permanent AF, were analyzed respectively.Results1. Compared with the control group, LAD was lager (P<0.05) in the AF group; compared with the cases of paroxysmal AF group, LAD was lager (P<0.05) in the cases of persistent AF; compared with the persistent AF group, LAD was lager (P<0.05) in the cases of permanent AF. There was no significant difference statistically of LVEF between the control group and the AF group.2. Compared with the control group, the serum level of hs-CRP was higher in the AF group (P<0.05); Compared with the cases of paroxysmal AF group, the serum level of hs-CRP was higher in the cases of persistent AF group and permanent AF group, but there was no significant difference between paroxysmal AF and control group.3. Compared with the control group, the serum level of Hey was higher in the AF group (P<0.05); Compared with the cases of paroxysmal AF, the level of Hey in the blood-serum was higher in the cases of persistent AF and permanent AF, but there was no difference between paroxysmal AF and control group.4.LAD has positive correlation with hs-CRP (r=0.617,P<0.01), LAD has positive correlation with Hcy (r=0.508,P<0.01). ConclusionThe inflammation, oxidative stress might take part in electrical remodeling and structural remodeling of left atrium as well as further promote the occurrence and development of AF. The intervention of inflammation and oxidative stress might provide a new clue in AF therapy.