The Analysis Of Risk Factoes In Type Two Diabetes Mellitus Patients With Atherosclerosis And The Relativity Between VDR-Fok Ⅰ、VDR Bsm Ⅰ Genetic Polymorphsms And Type2Diabetes Mellitus With Atherosclerosis

[objective]1. To investigate the states and the risk factors of Type2diabetes patients with AS.2.To detect the sensitivity and accuracy of exist examine methods of Type2diabetes patients with AS.[Methods]99T2DM patients were involved in this study. We investigate the clinic information、lab date and early examine methods of AS in those people, and recorded in questionnaires, and do the retrospective analysis.[Result]1. The prevalence rate of cervical plaque was29.3%(29/99), age and gender has no differences(x2=0.044, P>0.05; t=0.850, P>0.05).2. SBP, DBP, LDL, CIMT、history of smoke were significantly higher in plaques group than those without plaque group (P<0.05).3.Logistic analysis showed that LDL and CIMT were independent risk factors for incidence of cervical atheromatous plaques in type2diabetic patients (P<0.05). One unit of LDL added, the risky of AS is up1.7; one unit of CIMT added the risky of AS is up13.8.4. CIMT and baPWV is valuable for AS diagnosing then ABI. According to the best numerical value of sensitivity and difference, the best diagnosing number of CIMT is0.9mm and pwv is1560.[Conlusion] Cervical atheromatous plaques in type2diabetic patients are resulted from man yrisk factors, LDL and CIMT are independent risky factors of AS. Earlier intervention and controlling these factors will have clinic value for prevention and treatment macrovascular diseases of type2diabetes. PWV is1560is more diagnosive than1400for our hospital. [objective] To investigate the association of vitamin D receptor(VDR) gene polymorphism with diabetes mellitus in patients with AS.[Methods]99T2DM patients with AS were involved in this study. The VDR-Fok I and VDR-Bsm I genotypes were evaluated by polymerase chain reaction fragment length polymorphism (PCR-RLFP). The comparisons were made made of respective gene frequencies and allele frequencies between AS and non-AS T2DM patients.[Results] A slight significant association between type two diabetes patients with AS in Fok I homozygous ff genotype was observed comparing with FF(OR=8.056, sig<0.05). And comparing with BB homozygous genotype, Bb might be a protective genotype for type two diabetes patients with AS (OR=0.041, sig<0.05).[Conclusion] T2DM patients with AS showed slightly increased prevalence of ff genotype comparing with FF. And comparing with BB, Bb might be a protective genetype for type two diabetes patients with AS.