The Study In Elderly Patients With Cardiovascular Disease From Functional Community Hospital With Anti-platelet Agents

Objective： To investigate the degree and determinants of using anti-platelet agentsamong elderly cardiovascular disease patients from functional community hospital.Methods： The baseline characteristics and application status of anti-platelet agents ofthese patients were collected by questionnaire,described and analyzed．Results：1、191elderly cardiovascular disease patients were involved,and all of themhad the indication of using anti-platelet agents，but only70.16%patients were usinganti-platelet agents. Among those patients using anti-platelet agents，67.91%useAspirin,22.39%use clopidogrel.79.75%coronary heart disease patients withoutischemic stroke use anti-platelet agents,67.74%ischemic stroke patients withoutcoronary heart disease use anti-platelet agents, all of coronary heart disease patientscombined with ischemic stroke use anti-platelet agents.2、The taking rate of use Aspirin for primary prevention is63.83%. The taking rate ofanti-platelet agents in patients aged75and above was significant higher than aged75below (P＞0.05)．The taking rate of anti-platelet agents in patients with family historyof cardiovascular disease was significant higher than patients without family history ofcardiovascular disease（P＜0.05）.The taking rate of anti-platelet agents in patients withcoronary heart disease was significant higher than patients without coronary heartdisease（P＜0.05）. The taking rate of anti-platelet agents was no correlated with sex,smoking, BMI, hypertension and diabetes mellitus.3、The reason of patients not taking anti-platelet agents are as follows：A total of57 patients don’t use anti-platelet agents，of which49.12%patients lack sufficientunderstanding of the importance on the use of anti-platelet agents,28.08%patientsworry about the bleeding side effects and self-withdrawal，and22.8%patients don’ttake anti-platelet agents because of misdirecta from doctor.Conclusions：1、The taking rate of anti-platelet agents in this community hospital ishigher than the national average.2、Compared with secondary and tertiary hospitals, inthe community hospital the anti-platelet agents administration for secondary preventionin elderly patients with cardiovascular disease needs to be improved.3、The taking rateof anti-platelet agents was correlated with age, coronary heart disease, family history ofcardiovascular disease.4、Anti-platelet agents is not standardly used because the doctorsand the patients lack knowledge related to anti-platelet therapy. Objective:To study the intervention effect of anti-platelet agents on platelet activation inpatients with cardiovascular disease. Methods:Blood specimens were collected from all eligible patients to test theexpressions of CD36in platelet、platelet aggregation rate、the blood routine values andcoagulation system.Results:69old patients were enrolled in the study.1、The platelet aggregation rate by AA、ADP in Aspirin group was significant lowerthan control group（P＜0.05）；The platelet aggregation rate by AA、ADP inclopidgrel group was significant lower than control group（P＜0.05）；There was nosignificantly difference between Aspirin100mg daily and clopidgrel50mg daily inplatelet aggregation rate by AA、ADP（P＞0.05）.2、The expressions of CD36in platelet in Aspirin group was significant lower thancontrol group（58.49±8.33VS91.76±7.56，P＜0.05）；The expressions of CD36inplatelet in clopidgrel group was significant lower than control group（56.60±9.74VS91.76±7.56，P＜0.05）；There was no significantly difference between Aspirin100mg daily and clopidgrel50mg daily in platelet aggregation rate byAA、ADP（P＞0.05）.Conclusions:1、Anti-platelet agents can bring down CD36and platelet aggregationrate in elderly patients with cardiovascular disease and weakened prothromboticstate.2、Aspirin100mg daily and clopidgrel50mg daily have the same effects onbringing down CD36and platelet aggregation rate.