The Invasion Of Tumor Associated Macrophage And Regulatory T Cells In Gastric Stromal And Its Clinical Significance

Background.Tumor associated macrophage(TAM) and regulatory T cells(Tregs) are importantimmune cells in the most of tumors.It has been a lot of research and evidence provethat the TAM and Tregs can promote tumor development.but many papers onlyinvolved epithelial tumor,there is a few of research about mesenchymal tumor.so thisstudy is to investigate the relationship between TAM or Tregs and clinicopathologicalfeatures of gastic stromal tumor(GST),and the prognostic significance of TAM andTregs in GST also will be analyzed.ObjectiveTo evaluate the invasion of TAM and Tregs in GST and its clinical significance.MethodsThe proteins of CD68and Foxp3in64cases of GST were detected withimmunohistochemical staining,and the relationship between CD68or Foxp3andclinicopathological features of GST were analyzed.prognostic value of infiltrated TAMand Tregs was evaluated by Kaplan-Meier analysis.Resultsproteins expression of CD68and Foxp3in Intermidiate and High group were81.5%and88.9%,compared with54.1%and51.4%in low and very low group.Kaplan-Meier analysis suggest that infiltrated TAM and Tregs was associated withpoor prognosis.There was no significant correlation between the expression of CD68or Foxp3protein with age,gender,tumor location in patients with GST（p>0.05）,However,there was significant correlation between the expression of CD68or Foxp3protein with tumor stage（p<0.05）.ConclusionsTAM and Tregs in GST invasion and infiltration may promote tumorprogression,and was associated with poor prognosis.