| Objective：Milk protein allergy is the most common food allergy of baby. The incidenceof milk protein allergy has increased annually in recent years, due to changes in lifestyleand living environment. CMPA infant cases are collected for study, the basic situationsof milk protein allergy (CMPA) infant are analyzed, and the intervention&outcome ofsequential therapy through individualized application of amino acid formula powderinstead of deep hydrolysis formula powder is explored, so as to provide a reference formore active intervention method of infant milk protein allergy.Methods：Infants treated in pediatric clinic of Anhui Provincial Hospital from January,2011to March,2012who was in accordance with CMPA diagnosis and givennutritional intervention are chose as intervention object. Infants without nutritionalintervention due to social, economic or personal reasons are set as control group.Separate follow-up table is made for infant with milk allergy. After follow-up of6months, analysis is made for their family history, personal history, feeding situation,clinical manifestations, diagnosis and treatment.Results：120cases of CMPA infants. Male female ratio is1.61:1;16cases of prematureinfant;10cases of infants with low birth weight;16cases (13.33%) of exclusivebreastfeeding infants. Age of high incidence is2~4month (43cases,35.83%);76cases（63.33%）with family history of allergy. Clinical manifestations are various in manyorgan systems, most in2~4weeks after birth and mainly involving skin, respiratorysystem and digestive system. Respiratory system normally represents as wheezing andcough (48cases,40.00%), digestive system normally represents as diarrhea andconstipation (42cases,35.00%), and most infants (74cases61.67%) have eczema manifestations (urticaria, edema of lips and eyelid). The clinical symptoms of infantsfrom intervention group were improved significantly or disappeared within three weeks.However, clinical symptoms of control group appeared repeatedly. After three–monthnutrition intervention on CMPA infants of intervention group, the total effective rate is93.33%; the total effective rate of CMPA infants of control group is53.33%. There isbig difference between these two total effective rates, which has statistical significance.After six–month nutrition intervention on CMPA infants of control group, the totaleffective rate is92.22%; after six-month of conventional therapy on CMPA infants ofcontrol group, the total effective rate is70%. There is big difference between these twototal effective rates, which has statistical significance.Conclusion：Clinical manifestations of milk protein allergy are various and unspecific,which is vulnerable to misdiagnosis and mistreatment, and some negative consequencesmay be caused. Therefore, it is very necessary for medical staff to increase theawareness of food allergy and master the methods to identify it in clinical work for earlydetection, early diagnosis and early nutritional intervention, which is not only conduciveto the early rehabilitation of infants, improvement of life quality, but also significant onthe prevention of infant wheezing, allergic rhinitis, eczema, and maintain of normalintestinal function. For infants suspected as CMPA, diet avoidance and food challengetest are reliable clinical diagnostic methods. During food avoidance period, takingamino acid formula powder (AAF) is a good method to meet nutritional needs andremove allergens. Breastfeeding is helpful to avoid infant milk allergy, sequentialtherapy of amino acid formula powder instead of deep hydrolysis formula powder isvery safe and effective. Food containing milk protein should not be fed duringnutritional intervention period. Meanwhile, individualized nutrition intervention shouldbe given according to the infants’ family economic capacity, and changes in condition. |
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