The Related Research Between Klotho Protein And Mild Cognitive Impairment

Objective:To discuss Klotho protein in the pathogenesis of mild cognitive impairment in Uygur and Han nationalities in Xinjiang.At the same time,we explore whether there are differences about Klotho protein in different nations and genders and its correlation with lipids, blood glucose, blood pressure,age and other indicators.Methods:We do a MCI epidemiological survey in the elderly residents over60years of Xinjiang area old using a stratified random and multistage cluster sampling way. We screen data integrity161patients with MCI (Uygur nationality90people,Han nationality71people) as the MCI group. We select ethnic,gender and blood pressure matched161healthy populations (Uygur nationality88people,Han nationality73people) as the control group. ELISA is used to detect the Klotho protein concentrations in serum. Results:(1)The concentrations of Klotho protein of the case group (2.48±1.38) ug/L are obviously lower than the control group (3.07±1.39) ug/L (P<0.05).(2) The concentrations of Klotho protein of the Uygur nationality case group (2.21±1.30) ug/L are obviously lower than the Han nationality case group (2.81±1.42) ug/L (P<0.05).Also, the concentrations of Klotho protein of the Uygur nationality control group (2.84±1.36) ug/L are obviously lower than the Han nationality control group (3.34±1.37) ug/L (P<0.05).(3)The concentrations of Klotho protein of the male case group (2.29±1.08) ug/L are obviously lower than the female case group (2.65±1.60) ug/L. But there is no statistically significant difference between the two groups (P>0.05). The concentrations of Klotho protein of the male control group (2.91±1.18) ug/L are obviously lower than the female control group (3.22±1.55) ug/L. But also there is no statistically significant difference between the two groups (P>0.05).(4)There is negative correlation between Klotho protein and age(rs=-0.240, P=0.000). There is positive correlation between Klotho protein and Cholesterol,low-density lipoprotein,MMSE score and MoCa score (P<0.05).But There is no correlation between Klotho protein and Weight,abdominal circumference,blood glucos、blood pressure,high-density lipoprotein and so on (P>0.05).Conclusions:(1) Klotho protein is relationed to the pathogenesis of MCI. So we speculate that its reduced concentrations inside the body may contribute to the occurrence and development of MCI.(2) There may be differences about Klotho protein concentrations in different nations,Uygur lower than Han nationality. But there is no differences about Klotho protein in different genders.(3) With the increasing age, the content of Klotho protein inside the body may be gradually reduced.(4)Klotho protein may have relation with low density lipoprotein and cholesterol.But Klotho protein have no relation with blood glucose、blood pressure and high density lipoprotein、Weight and abdominal circumference.