The Expression And Significance Of The CD11c~+CD123~-Myeloid Dendritic Cells In The Patients With Rheumatoid Arthritis

Objective:To investigate the quantity of CD11c~+CD123~-myeloid dendritic cells inthe peripheral blood of patients with new-onset and active rheumatoid arthritis (RA), toexplore its role in the RA.Methods:Collected the anticoagulant peripheral blood and joint fluid of RA patients andcontrols. Detected the percentage of CD11c~+CD123~-myeloid dendritic cells by flowcytometry. Analyse the correlation between the quantity of CD11c~+CD123~-myeloiddendritic cells and the level of anti-CCP, CRP, RF, ESR, DAS28， joint swelling numberand joint pain number.Result: The CD11c~+CD123~-myeloid dendritic cell in the peripheral blood of RA werelower than that in ncontrol (P<0.05). The CD11c~+CD123~-myeloid dendritic cell in thejoint fluid of RA were higher than that in ncontrol (P<0.05).The peripheral blood of mDCquantity are difference between different disease activity of RA patients. Correlation wasfound between levels of CD11c~+CD123~-myeloid dendritic cell and anti-CCP, CRP, RF,ESR, DAS28, joint swelling number,but there were no correlation found between thelevels of CD11c~+CD123~-myeloid dendritic cell and joint swelling number.Conclusion:The transformation of CD11c~+CD123~-myeloid dendritic cells may lead toimmune dysfunction, which can promote the development of the disease.