Correlation Between Virus Infections And Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective: To discuss the correlation between virus infections and acuteexacerbation of chronic obstructive pulmonary disease,and effects of bloodgas analysis. Methods: The sera were collected from200c acuteexacerbation of chronic obstructive pulmonary disease patients and weresubjected to simultaneous detection of immunoglobin M of nine majorpathogens, including Legionella pnettmophila(LP), Mycoplasmapneumonia(MP), Coxiella burneti(COX), Ghlamydia pneumoniae(CP),adenovirus(ADV), respiratory syneytial virus(RSV), influenza A virus(IFA),influenza B virus B(IFB)and parainfluenza virus(PIVS)type1,2and3, viaindirect immunofluorescence assay,and divided200patients into two groupsby blood gas analysis,the group of respiratory failure and group of non-respiratory failure,to analysis the positive rate of each pathogen and in twogroups. Results:62cases of AECOPD patients etected antibodies, the totalpositive rate was31%(62/200), the infection rate of virus was the hight, IFBaccounted for13.5%（27/200），RSV accounted for4%（8/200）, IFAaccounted for3.5%(7/200)， ADV accounted for3%（6/200）， PIVSaccounted for2%（4/200），in atypical pathogens, MP accounted for7.5%（15/200），LP accounted for5%（10/200）, COX accounted for0.5%（1/200）; and there were9cases in Combined2pathogens infection,ccounted for14.5%in total positive cases, and4cases in Combined3pathogens infection, ccounted for2%in total positive case. Conclusion: respiratory pathogen infection is an important incentive for AECOPD, themost common respiratory virus pathogens, there were high positive rate ingroup respiratory failure than group of non-respiratory failure withAECOPD,and the Combined pathogens infection in common in patientswith AECOPD.