The Relationship Between Damage Of Target Organs And Resting Heart Rate In Young Hypertension

Objective:To investigate the relationship between resting heart rate（RHR）and thedamage of target organs in young hypertensive patients. Methods:A total of677primaryhypertensive patients aged from18to45was chosen from the first affiliated hospital ofXinjiang Medical University from January,2009to January,2012,and hypertensives weredivided into three groups according to their RHRs:group A(RHR<70bpm,n=170),groupB(70bpm≤RHR<80bpm,n=266),and group C(RHR≥80bpm,n=231).（1）Indexes of leftventricular structure and systolic function were examinated by ultrasound cardiograph.The influencing factors of left ventricular structure and systolic function were analyzed byvariance analysis and multi-factor Logistic regression analysis.（2）Carotid artery structurewas examinated by ultrasound. The groups of carotid artery related parameters werecompared and analyzed by completely random design analysis of variance.（3）The renalfunction was examniated. The parameters related to kidney function were compared andanalyzed by completely random design of variance analysis. Results:(1)The differences inthe blood pressure between the three groups had statistic significance(P<0.05)；（2）so didthe differences in the left ventricular end-systolic dimension,left ventricular mass,and leftventricular ejection fraction(P<0.05).The left ventricular end-systolic dimension,nterventricular septal thickness,left ventricular massand left ventricular mass indexweresignificantly higher in group C than in group B(P<0.01or P<0.05),while the leftventricular ejection fraction were significantly lower in group C than in group B(P<0.01).Multi-factor Logistic regression analysis showed that body mass index(BMI) was one ofthe risk factors of left ventricular end-diastolic dimension(OR value=1.078) and leftventricular end-systolic dimension(OR value=1.084),and the admission systolic bloodpressure was one of the risk factors of left ventricular posterior wall thickness(OR value=1.020),left ventricular end-systolic dimension(OR value=1.017) and left ventricularmass index(OR value=1.037).(3)The comparison of three groups of carotid artery structureshows:the right side of the carotid artery diameter in group A was higher than groupC(P<0.05),the left carotid artery diameter was higher than group B,group A left carotidartery diameter of group A was higher than group C(P<0.05).Conclusions:(1)In younghypertensive patients,BMI is one of the risk factors of left ventricular end-diastolicdimension and left ventricular end-systolic dimension.(2)Admission systolic bloodpressure was one of the risk factors of left ventricular posterior wall thickness,leftventricular end-systolic dimension and left ventricular mass index.(3)Different levels ofRHR have different effect on the left ventricular functure and systolic function.(4)RHR isnot the risk factor of left ventricular functure and systolic function.(5)Resting heart rateincreased carotid artery diameter in young patients with high blood pressure has atendency to decrease.