Case-control Study On Risk Factors Of Cervical Cancer In Rural Women Of Wuhan

ObjectiveThis paper aims to investigate the incidence and distribution of cervical cancerof rural women in Wuhan, to analyze main factors of cervical cancer and theinteraction of these factors, to have risk assessment and discrimination of various riskfactors, to establish early identification and early warning systems and to developintervention decisions of cervical cancer risk factors.Methods1.Survey methodsBased on1:1case-control study method, individual study is applied according tolocation and age designed in the questionnaire meeting cervical cancer risk factors inWuhan which is based on domestic and foreign cervical cancer literature as well asmaternal and child health and epidemiology expertise. Case group is composed by722cases of cervical positive lesions (cervical cancer diagnosed condition graded asCIN1and more patients), while control group is composed by722cases of cervicalcancer diagnosed negative. 2.Statistical methodsAfter checking,verification and encoding, the data are input to computer toestablish a database with Epidata3.0by double-entry method, of which10%arereviewed. Statistical analysis of data is conducted with SPSS18.0and SAS9.2,including descriptive analysis,2test, paired t test, univariate analysis, multivariateConditional Logistic Regression Analysis, etc.Results1.The status of cervical cancer screening project in rural areas of Wuhan.There are170,401rural women taking the cervical cancer screening inWuhan.The referral rate is66.49%. there are764cases of cervical precancerous lesions and37cases of cervical cancer in this screening. The prevalence of cervical cancer is32.66/100000overall according the referral rate. The number of patients in HuangpiDistrict is the most over all districts. Womenof CINⅠ-Ⅲgrade lesions are agedmainly between35to50years old, and women of cervical cancer-positive are agedover35years old.2. The influencing factors for cervical cancer in rural areas of Wuhan1). The result of univariate analysis suggests that17factors are significantlyassociated with the incidence of cervical cancer, including age of marriage, use ofphone or hairdryer in life, exposure to noise and glare, gynecological diseases,vaginal bleeding after intercourse, vaginal secretion bloody or yellow liquid, bilateraloophorectomy, gynecological diseases, HPV infection, age of menarche, menstrualduration, age of menopause, age of sexual debut, whether or not to have aharmonious sex life, passive smoking, frequent upset for no reason to worry about theability to regulate emotions.2). The result of multivariate conditional logistic regression analysis suggests that5factors are significantly associated with the incidence of cervical cancer, includingage of menarche, vaginal bleeding after intercourse, vaginal bloody or yellow liquid,HPV infection, cervical cancer family history. They all are the risk factors of cervicalcancer. ConclusionThe prevalence rate of cervical cancer in rural areas screening is overall27.13/10, which is higher than the national level. Health education on women’sreproductive health care should be carried out through extensive forms and multiplechannels to prevent risk factors for cervical cancer. Publicity and education shouldbe strengthened to help people live a healthy lifestyle. People who have a familyhistory of the disease should strengthen health care, and carry out regularstandardized physical examination. Cervical cancer should be detected and treatedas early as possible.