The Role Of The Complement Receptor1and3on Neutrophils In Diagnosing Bacterial Infection Diseases

Background: Neutrophils complement receptors are a part of the body’s natural immune.The purpose of this paper is to study the role of the complement receptor l and3onneutrophils in diagnosing bacterial infection diseases.Methods: We collected98peripheral blood specimens coming from clinical researchobjects, including25cases of septicemia,32cases of local infection,21cases of viralinfection, and20cases of healthy control. Flow cytometric immunological method wasapplied to determination the mean fluorescence intensity (MFI) of peripheral bloodneutrophils complement receptor1(CR1) and neutrophils complement receptor3(CR3),and collected peripheral blood leukocyte count and CRP of the cases. Maked a comparisonwith the expression of peripheral blood neutrophils CR1and CR3, and evaluated theusefulness of neutrophils CR1and CR3in diagnosing bacterial infectious diseases.Results: The levels of CR1and CR3in bacterial infection groups (including sepsis groupand local bacterial infection) were significantly higher than that in the normal control group(p <0.05). Compared with the viral infection group, CR1, CR3and CRP in bacterialinfection groups were significantly increased (p <0.05). However, CR1only in the sepsisgroup was higher than that in the viral infection group. CR1, CR3and WBC in the sepsisgroup were higher than those in the local bacterial infection group (p <0.05). But CRP hadno statistical difference in the viral infection group and the normal control group (p>0.05).According to the receiver operating characteristic curve, the best threshold of CR1indiagnosis of infection was20.50with the sensitivity of92.0%and the specificity of35.6%.And the best threshold of CR3was76.73with the sensitivity of98.0%and the specificityof6.7%.Conclusions:1. CR1and CR3were significantly higher in bacterial infections diseases. Interms of prompting the severity of bacterial infection, CR1, CR3and WBC were superior toCRP.2. When diagnosing bacterial infection diseases, CR1and CR3have high sensitivity, but poor specificity. So they can not be applied to diagnose bacterial infection diseasesalone.