Electricity For Non-alcoholic Fatty Liver In Rats Binding Protein4and Lipid Metabolism

Objectives: Nonalcoholic fatty liver disease (NAFLD) is a kind of hepaticsteatosis induced by many complex factors, featured by the accumulationof lipid such as triglycerides (TG) and total cholesterol (TC) in the hepaticcells. The incidence of fibrosis can reach to25percent, of which1.5–8percent exacerbate into cirrhosis. An increasing number of people areconsidering the damage of fatty liver and more attention is paid on thecuring of this disease. We tested the concentrations of retinol-bindingpretein4(RBP4), adipinectin(ADP), leptin(LEP), free fatty acids(FFA) to toinvestigate therapeutic effects of electroacupuncture on liver function andlipid metabolism in NAFLD rats.Methods:44rats were randomly allocate to4groups, each with11rats:control group, electroacupuncture group (EA), EA non-acupoint (NEA) andnormal group. EA(2Hz,1.5mv,15min) was applied to unilateral“Fenglong”(ST40),“Zusanli”(ST36),“Sanyinjiao”(ST6) and “Taichong(LR3)”,once daily for4weeks. After the treatment, to detect the retinol binding protein4(RBP4), adipinectin (ADP) and leptin (LEP) byEnzyme-linked immunosorbent assay (ELISA), levels of aspartateaminotransferase (AST), valley seum ALT (ALT),total cholesterol (TC),triglycerides (TG), high density lipoprotein (HDL) and low densitylipoprotein (LDL) contents were detected by chromatamety.Results: Compared with normal control group, levels of serum AST，ALT，TC，TG, HLD, LDL and RBP4, ADP, LEP in EA group were decreasedsignificantly (P<0.05) and fatty degeneration in hepatic tissue was reduced;no significant change in both serum and hepatic tissue was found in theNEA group (P>0.05).Conclusions: EA has a positive effect on the reduction of liver loadthrough reducing the levels of serum RBP4, LEP, LD, FF, TC, TG andincreasing ADP and HDL in NAFLD rats, thus improves the liver function.