| ObjectiveMulti-system damage can appear in the infectious mononucleosis, andmost common is the liver damage. But the related research of the liverdamage is less. Alanine aminotransferase is one of the most importantenzymes in liver function, and serum levels of ALT is a major biomarkers indiagnosis of liver damage. To follow-up of liver function in children with IMin Chongqing and the clinical characteristics of IM complicated with liverfunction damage and ALT through retrospective case analysis of infectiousmononucleosis and to provide the basis for the prevention and treatment ofIM complicated with liver function damage.MethodsAll results of liver function of IM in Chongqing Children’s Hospitalfrom October in2011to October in2012were collected, and were followedup for2months. At the same time, the clinical information of IM werecollected accordingly. The data was counted using statistical analysis ofChi-Square Test by general information (gender and age), the major clinical signs and symptoms (fever, duration of fever, angina, swollen lymph nodes,rash, hepatomegaly, spleen enlargement, eyelid swelling, headache and nasalcongestion), laboratory examination, disease severity, treatment outcomeand IM complicated with liver damage and ALT.Results1The cases of IM complicated with liver damage were74/93(79.6%),and the cases of liver damage in2ULN＜ALT≤5ULN were29/74(39.2%).The cases of IM complicated with AST were63/93cases (67.7%), and thecases of AST in2ULN＜ALT≤5ULN were23/63(36.5%). The levels ofALT and AST began to rise with IM in2days after,and were duration peak in1-2weeks. The levels of ALT and AST back to normal with81.1%and81.1%respectively after3weeks, and which were94.6%and94.6%respectively after4weeks.2The average age of IM was4.9, and the cases of IM in2to6yearswere56/93(60.2%). There was difference of IM complicated with liverdamage and ALT by age (P<0.05). The ratio of male to female with IM was1.21:1, and the ratio of IM complicated with liver damage was1.31:1, butthere was no difference of IM complicated with liver damage and ALT bygender (P>0.05).3The main clinical signs and symptoms were fever (85/93,91.4%),pharyngitis (79/93,84.9%), enlarged lymph nodes (75/93,80.6%),hepatomegaly (58/93,62.4%), splenomegaly(60/93,64.5%), hepatosplenomegaly (49/93,52.7%). There was difference of IMcomplicated with liver damage and ALT by duration of fever, hepatomegaly,splenomegaly and hepatosplenomegaly (P<0.05), but there was nodifference of the other clinical manifestations(P>0.05).4The cases of IM with Peripheral blood WBC (＞10×109/L) were88/93(94.6%), hemoglobin (＜110g/L) were12/93(12.9%), platelet (＜100×109/L) were12/93(12.9%), abnormal lymphocyte count (≥10%) were61/93(65.6%). There was difference of IM complicated with liver damageand ALT by platelet (＜100×109/L) and abnormal lymphocyte count (≥10%)(P<0.05), but there was no difference of the other clinicalmanifestations(P>0.05).5The cases of mild group in IM were33/93(35.5%), moderate groupwere49/93(52.7%), severe group were11/93(11.8%). There was differenceof IM complicated with liver damage and ALT by degree of IM(P<0.05). Nodeaths of IM through support therapy.Conclusion1The proportion of IM complicated with liver damage was79.6%,and the proportion of IM complicated with AST was67.7%. The increasedlevels of ALT and AST mainly between the2ULN-5ULN,39.2%and36.5%,respectively. The levels of ALT and AST began to rise with IM in2daysafter, up to peak in1-2weeks, returned to normal4weeks later.2Infectious mononucleosis usually occurs to preschool children. Fever, pharyngitis, lymphadenopathy, hepatosplenomegaly were the mainclinical manifestations. There was difference of IM complicated with liverdamage and ALT by duration of fever, hepatosplenomegaly,thrombocytopenia, and increased number of abnormal lymphocytes.3Multi-system damage can appear in the infectious mononucleosis,and there was difference of IM complicated with liver damage and ALT byDegree of illness. Prognosis is good through support therapy... |
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