Synthetic Studies On Substituted Phenyl α-L-Rhamnosides And RGDY-papM6p

The thesis includes two parts:1. Synthetic studies on substituted phenyl α-L-Rhamnosides.2. Synthetic studies on RGDY-papM6p1. Substituted phenyl α-L-Rhamnosides are important for their application in investigating the substrate-specificity of α-L-rhamnosidase and they also serve as synthetic intermediate for glycosidic compounds. we applied phase-transfer catalysis to the synthesis of substituted phenyl α-L-Rhamnosides and acquired favorable results(-98%). The "glycosylation-deacetylation" one-pot approach simplified the synthesis of the aromatic rhamnoside, avoided the use of high poisonous reagents greatly and operated easily.Furthermore,the efficient applicability of this methodology in scale-up conditions makes the idea more worthy for further reseach.2.Liver cirrhosis is a large class of disease which brings serious harms to human beings.People found that hepatic stellate cell(HSC) plays a key role during hepatic fibrosis,RDG and M6p have dual function of antagonist and specific targeted compound。We synthetized papM6p and Boc-RGDY successfully and we have carried on investigation in the synthesis of RGDY-papM6p,but haven’t got the pure target material.