Impact Of Obstructive Sleep Apnea Hypopnea Syndrome On Fatigue In Patients With Acute Cerebral Infarction

Objective To investigate the impact of obstructive sleep apnea hypopnea on fatiguein patients with acute cerebral infarction.Methods All the consecutive selected patients with acute cerebral infarction bycranial magnetic resonance imanging(MRI) comformed complete FSS(FatigueSeverity Scale) score, then divided into two groups FSS＜4and FSS≥4, all patientscomplete video polysomnography(PSG) examination, then divided into four groupsAHI＜5,5-15,16-30,≥30following the apnea hypopnea index(AHI). The control groupwas the normal population without cerebral infarction by cranial MRI confirmed.Comparative the clinical features between cerebral infarction group and non-infarctiongroup, fatigue and non-fatigue, comparative the impact on cerebral infarction andnon-infarction of sleep-breathing disturbance.Results82acute cerebral infarction patients and54normal subjects was enrolled inthis study. There are no difference in age,gender,body mass index between this twogroup.There are51(62.2%,51/82) acute cerebral infarction patients whose FSS surpassor equal to4scores,49acute cerebral infarction patients combine sleep-breathingdisturbance,45(88.2%,45/51) patients are OSAHS,1(2%,1/51) patients isCSAHS,3(5.9%,3/51) patients are MSAHS;31(37.8%,31/82) acute cerebral infarctionpatients whose FSS are under4scores,3(9.7%,3/31) patients combine sleep-breathingdisturbance, which all are OSAHS. There are9(16.7%,9/54) normal subjects whoseFSS surpass or equal to4scores,8(88.9%,8/9) normal subjects combinesleep-breathing disturbance which all are OSAHS;45(83.3%,45/54) normal subjectswhose FSS are under4scores,2(4.4%,2/45) normal subjects combine sleep-breathingdisturbance which all are OSAHS. OSAHS can cause fatigue both in normal subjectsand acute cerebral infarction patients(P＜0.001), but the FSS score in acute cerebralinfarction patients higher than FSS score in normal subjects,what’s more acute cerebralinfarctiou patients often accompany more obvious subjective discomfort,daytimedysfunction and consider fatigue as one of the most serious symptoms(P＜0.05). In theacute cerebral infarction group, the heavier OSAHS then the more serious fatigue(P＜ 0.001); The analysis that the realationship between infarction location and OSAHSserious, fatigue serious shows no significan difference between infarction location andOSAHS serious,fatigue serious(P＞0.05).Conclusions The incidence of poststroke fatigue is high, OSAHS may be the mostsignificant risk factor that impact the poststroke fatigue. Early screening,assessmentingand intervening OSAHS in acute cerebral infarction patients may alleviate poststrokefatigue,improve patents’ outcome and quality of life.