The Application Of Ultrasonic Elastography Strain Histogram In The HepatitisC And Non-alcoholic Fatty Liver Disease Diagnosis

Objective:To explore the value of evaluation of hepatic stiffness in hepatitisC and non-alcoholic fatty liver disease by ultrasonic elastography using tissue dispersion quantitative analysis software.Methods Tissue dispersion quantitative analysis software was applied to30health control people and30non-alcoholic fatty liver disease patients and30hepatitisC patients to analyse the hepatic stiffness. Eleven characteristic quantities of elastography imaging were obtained by the tissue dispersion quantitative analysis software,including average relative strain value(MEAN), standard deviation of relative strain value (SD),area ratio of low-strain region(%AREA),complexity(COMP), kurtosis(KURT),skewness(SKEW),contrast(CONT),entropy(ENT),invers e different moment(IDM), angular second moment(ASM),and correlation (CORR).Liver fibrosis index (LF index) was derived from the eleven quantities.The differences of the12quantities between three groups were analyzed.Meanwhile, Fibroscan was used for liver stiffness measurement (LSM) of30hepatitisC patients.The correlation between fibroscan and real-time tissue elastography was analyzed.Results The MEAN, SD,%AREA, COMP, KURT, SKEW, CONT, ENT, IDM, ASM, CORR of elastography imaging obtained by the tissue dispersion quantitative analysis software between the three groups observed the characteristic quantities had statistically significant differences between30health control people and30non-alcoholic fatty liver disease patients except KURT,SD.The characteristic quantities had statistically significant differences between30hepatitisC patients and30health control people except SD.The characteristic quantities had no differences between30hepatitisC and30non-alcoholic fatty liver disease patients. Fibroscan was closely related to RTE.Conclusion Real-time tissue elastography effectively diagnosed in the diffuse liver disease, and evaluated development of hepatic pathological change.RTE has a sonography-based new method in assessment of liver fibrosis.