Significance Of Cholinesterase(CHE) Activity In Patients With Chronic Obstructive Pulmonary Disease And Respiratory Failure

Objective To explorer the clinical characteristics and significance of theserum cholinesterase activity change in patients with chronic obstructivepulmonary disease(COPD) and respiratory failure.Methods47patients with chronic obstructive pulmonary disease andrespiratory failure were collected from the respiratory intensive careunit(RICU) of the First affiliated hospital of Chongqing medicaluniversity,at the same time30normal cases were admitted from the hospitalphysical examination center as control. For all of the observation grouppatients， their serum CHE and liver function were detected next morningand given APACHE II score within the first24hours. Besides，the levels ofthe serum CHE and liver function were also detected in the control group.The47patients with COPD and respiratory failure were divided into twogroups based on their effect of satisfaction or not：the good satisfactiongroup(n=30)and the bad satisfaction group(n=17) after a week treatment.Cholinesterase actiity and APACHE Ⅱ score of the two groups were compared.Results The cholinesterase activity, serum pre-albumin (PA) and plasmaalbumin of observation group were significantly lower than the controlgroup (P <0.01).ALT, AST had no statistical difference (P>0.05). Theserum cholinesterase activity, plasma albumin and serum albumin of thebad satisfaction group is lower, the APACHE Ⅱ score higher compared tothe other one(P <0.05). Pearson correlation analysis: the serum ChE weresignificantly negatively correlated with APACHE Ⅱ score.and positivelycorrected with PA, plasma albumin(respectively r is-0.863,0.799and0.890, P <0.01).Conclusions The changes of serum CHE activity can reflect the severity ofthe patients’ conditions and their prognosis who had chronic obstructivepulmonary disease and respiratory failure. Clinicians should be vigilant ofpatients with cholinesterase decreased.