The Value Of Monitoring Serum Levels Of Estradiol （E₂） And Progesterone （P） During Early Pregnancy

objective: To discuss the significance of dynamically monitoringestradiol（E₂）and progesterone（P） during the early pregnancy.Methods: Retrospective analysis which included312women wasdone to the serum E₂and P levels during their early pregnancy. Womenwere divided into the continuous pregnancy group （n=280） and theinevitable abortion group （n=32）. The sensibilities and specificities of E₂and P were analyzed on predicting the inevitable abortion.Result:1) The E₂levels of the continuous pregnancy group and theinevitable abortion group were448.55±253.29pg/ml and304.79±161.32pg/ml respectively in35-45days’ gestation （P<0.01） The serum E₂level ofthe continuous pregnancy group increased rapidly and was positivelycorrelated with pregnancy time （r=0.822, P<0.01），and its growth rates inevery period of the early pregnancy time were higher than that in theinevitable abortion group （P<0.01）; The growth rate in continue pregnancygroup was higher than the inevitable abortion group （P<0.01）;2) The serum P value of35-45days’ gestation was between17.3ng/ml and40.6ng/ml in the continue pregnancy group, and between8.32ng/mland40.5ng/ml in the inevitable abortion group.The serum P level in thecontinue pregnancy group is relatively stable and increased slightly；3) The sensibilities on predicting the inevitable abortion were96.77%、87.1%、74.2%（P<0.01or P<0.05）,specificities were88.75%，93.75%，92.5%respectively（P>0.05），and accuracies were91.0%，91.9%and87.4%respectively （P>0.05）.Conclusions: The E₂+P determination is a reliable indicator to predictinevitable abortion, it can avoid the influence of premature and frequent Bultrasound examination to embryo and missed abortion, and can berecommended in clinical monitoring in early pregnancy...