The Expression And Clinical Significance Of STAT1and COX-2in Non-small Cell Lung Cancer

Objective:To explore the expression of Signal transducer and activator oftranscription-1and Cyclooxygenase-2in non-small cell lung cancer,andanalyzed the relationships of STAT1and COX–2among the patientage,pathological classification,degrees of differentiation and gender innon-small cell lung cancer. Explore the roles of STAT1and COX–2in thegrowth and metastasis in non-small cell lung cancer.Methods:Collect60specimens of non-small cell lung cancer patients whounderwent surgical resection at the affiliated hospital of Luzhou MedicalColeldge from May2012to October2012, also collect30specimens of normallung tissues as a control group. All selected objects had no other lung diseases,without preoperative chemotherapy, radiation therapy before operation.Pathology classification were detected by Hematein-Eosin staining; express ofSTAT1and COX-2in the non-small cell lung cancer and normal lung cancertissue were detected by the immunohistochemical staining; analyzed thecorrelation between STAT1and COX-2in the age, histological type, gender,cell differentiation of non-small cell lung cancer patients.Results:①Compared with normal pulmonary tissues, expression ofSTAT1and COX-2in the non-small cell lung cancer tissues were increasedsignificantly (P<0.05);②Compared with Ⅱ, Ⅲ and Ⅳ stage,the expressions of STAT1in I stage of NSCLC were increased significantly (P<0.05);③Compared with Ⅱ, Ⅲ and Ⅳ stage,the expressions of COX-2in I stage ofNSCLC were decreased significantly (P<0.05);④The expressions of STAT1and COX-2in the lung cancer tissue were not related with the patientage,pathological classification,degrees of differentiation and gender （P＞0.05）;⑤The Spearman rank correlation analysis indicated that STAT1andCOX-2were negative related, r=0.718（P <0.5）.Conclusions:①STAT1and COX-2were involved in the formation ofnon-small cell lung cancer;②STAT1and COX-2were associated with theprogress of non-small cell lung cancer;③STAT1and COX-2in the process ofnon-small cell lung cancer may have antagonistic effections.