Analysis Of87Cases Of Primary Hepatocellular Carcinoma

Objective: To explore relationship of age、sex、background of liver disease andAFP influence factors for primary hepatocellular carcinoma，the AFP for diagnose ofprimary hepatocellular carcinoma;the effects on the patiens＇tumour recurrence ofpreventive Transcather arterial chemoembolization(TACE) treatment after operation.Methods: Retrospectively analyzed clinical data of87patients who receivedpartial liver resection due to primary hepatocellular carcinoma from2008,8to2012,8in my hospital.Results: Men have69cases, accounting for79%, women have18cases,accounting for21%. Patients of hepatitis B surface antigen positive have75cases,accounting for86.2%, patients of hepatitis B surface antigen negative have12cases,accounting for13.8%. Patients of Big Three Postive have17cases, accounting for19.5%. Patients of Small Three Postive have46cases, accounting for52.9%. AFP risein43cases, accounting for49.4%, It was showed that the AFP levels were not related tohepatocirrhosis、age、hepatitis B surface antigen，but the size of tumor、location ofTumor (P<0.05).12cases occur from Percutaneous radiofrequency ablation (PRFA)with those of patients with postoperative recurrence of hepatocellular carcinoma(RHCC), ten were complete ablation(CA)， two was were non一completeablation(NCA). The CA rate of masses (≤3) was90%(9/10)，the CA ofmasses (3-5cm) was50%(1/2).7of12Patients，AFP rose Preoperation,6fellPostoperation, l in7become negative. All the patients have successfully treated withoutserious complications. Patients were divided into two groups: experimental group(30cases) with TACE treatment after hepatectomy and control group(45cases) withoutTACE trearment. The tumour recurrence rate in the first year was20.1%forexperimental group,38.7%for the control group, which indicated significantdifference(p<0.01). However the tumour recurrence in the second and third year was52%,75%for the experimental group and56%,80%for the control group, which suggested no significant difference (p>0.05).Conclusions: AFP is significant for hepatocellular carcinoma which is one of thebest forepart diagnose now, but it is affected by many factors; HBV infection which is arisk factor for hepatocellular carcinoma is closely related with hepatocellularcarcinoma. The risk factor is especially Small Three Postive, the second is Big ThreePostive. So we should pay high attention to Small Three Postive. PRFA is morecost-effective、successful、less invasive and should be considered an eligible treatmentfor recurrent HCC. Especially PRFA apply that the size of tumor is≤3cm. PreventiveTACE treatment after hepatectomy for primary hepatocellular carcinoma cansignificantly decrease the patients＇short-term tumour recurrence rate.