Discussion Of Clinical Significance Of Changes Of Serum CA125、CA19-9、AFP And CEA Levels In Patients With Hepatic Cirrhosis

Objective：To the clinical significance of changes of serum CA125、CA19-9、AFP and CEA levels in patients with liver cirrhosis.Mdthods:120cases of patients had been diagnosed as liver cirrhosis by clinical、biochemistry、CT or MRI were selected between January2010and September2012inour hospital as experimental group and divided into groups according to Child-Pughclassification and the levels of ALT、DBiL and TBA.50normal persons from ourhospital for physical examination were selected between January2010and June2010ascontrol group. The levels of serum CA125,CA19-9, AFP and CEA were measured bycobas E411、E601full-automatic immunochemiluminescence. The relationship betweenthe four tumor markers and Child-Pugh classification and with ascites and ALT、DBiL、TBA was analyzed with software SPSS (version17.0).Results：1、The comparison of the levels of serum CA125、CA19-9、AFP and CEAbetween cirrhosis patients group and healthy control group: The levels of serumCA125,CA19-9and AFP of cirrhosis patients were significantly higher than that ofnormal persons (P＜0.01or0.05), the levels of serum CEA rose in several patients withliver cirrhosis, but had no significant difference compared with normal persons (P＞0.05)；2、The comparison of the levels of serum CA125、CA19-9、 AFP and CEA indifferent Child-Pugh classificantion: the levels of serum CA125、CA19-9、AFP weresignificantly rose in patients of Child C with liver cirrhosis in different Child-Pugh classificantion, the difference had statistics value(P＜0.05), the levels of serum CEA inChild-Pugh classificantion had no statistics value(P＞0.05).3、The comparison of the levels of serum CA125、CA19-9、 AFP and CEA incirrhosis patients with ascites or not: the levels of serum CA125in patients withascites were significantly higher than that of patients without ascite（sP＜0.01）the levelsof serum CA19-9、AFP and CEA had no significant difference in the patients withascites and without ascites(P＞0.05).4、The comparison of the levels of serum CA125、CA19-9、 AFP and CEA incirrhosis patients with the liver biochemical indicators rose or not: the patients withALT、DBiL、TBA levels rose,whose levels of serum CA125、CA19-9and AFP weresignificantly higher than that of normal levels of ALT、DBiL and TBA，the differencehad statistics value(P＜0.05).Conclusion：1、The levels of serum CA125in patients with cirrhosis associated with the hepaticfunction damage degree and the presence of ascties；2、The levels of serum CA19-9and AFP in patients with hepatic cirrhosis ishelpful for assessing of the severity of diseases.