The Prognostic Value Of Impaired Glucose Tolerance In Patients With Coronary Artery Disease Treated With Percutaneous Coronary Intervention

Backgrounds A large study showed that,compared with the blood sugar normalprognosis after stent implantation in patients with coronary heart disease, the prognosisof coronary heart disease patients with diabetes mellitus after stent implantation ispoorer.there is also evidence that IGT is very frequent in CHD patients.however,theprognostic value of IGT in CHD patients treated with percutaneous coronaryintervention (PCI) remains unclear.Aims To assess the incidence and impact of IGT on major adverse cardiovascularevents(MACE)in CHD patients treated with PCI.Methods The study population consisted of163consecutive patients admitted to ourdepartment with non-diabetic CHD and treated with PCI between January2009andFebruar2012. After the glucose tolerance test，Found that NGT69patients，IFG4patients，IGT73patients，DM17patients. Meet the inclusion criteria and agreed tofollow-up in100patients.Patients with IGT comprised a IGT group, the patientswithout any glucose disturbances constituted the NGT group. Standard oral glucosetolerance test(OGTT)was performed during stable condition and interpreted accordingto WHO criteria. The mean follow-up period was12months.All patients after theintervention, received100mg of aspirin and75mg clopidogral daily,as well asbeta-blockers,ACE inhibitors/angiotensin receptor blockers(ARB) and statin,if theseagents had not been contraindictated.Results1.Sex、age、smoking、family history、BMI and blood lipid did not differsignificantly between study groups.（P＞0.05）2. In163non-diabetic patients with coronary heart disease (CHD),44.8%of patients combined glucose tolerance.3.During1-year follow up incidence of unstable angina was significantly higher in IGT group in comparison to NGT grou（pP＜0.05）.There were no differencesin acute myocardium infarction、heart failure、sudden death and stroke rate eventsbetween study groups（P＞0.05）.Conclusions In a population of CHD treated with PCI, subjects with IGT haveunfavorable one year prognosis,our data confirmed the importance of OGTT performedbefore hospital discharge in detection of glucose abnormalities in non-diabetic CHDpatients treated with PCI.Antidiabetic treatment would be necessary to reduce the riskof cardiovascular events.