The Study Of Traditional Chinese Medicine Syndrome Rules Of Untreated Secondary Pulmonary Tuberculosis

ObjectiveStudy the law of syndromes of untreated secondary pulmonary tuberculosis and the influences in traditional Chinese medicine syndromes distribution of sex, age, course of disease and laboratory indexes, to guide clinical practice further.MethodsChoosing150cases with who diagnosis untreated secondary pulmonary tuberculosis from2010January to2010December in Chengdu surrounding areas, collecting their TCM diagnostic information, testing their reference laboratory indexes and creating database.Then using Ward method clustering to explore the law of syndromes of the cases and the relationship between TCM syndrome distribution and age, course of disease and laboratory indexes.Results1. TCM law of syndromes preliminarily divided into three categories by Ward method clustering:The first category of a total of29cases, the second category of a total of83cases, the third type of a total of38patients.2. Clinical diagnosis:Lung Yin deficiency accounted for60.7%, both Qi and Yin deficiency accounted for20.7%, Fire excess from Yin deficiency accounted for14%. Clinical diagnosis and the result of clustering analysis through statistical analysis, P<0.05, shown consistency.3. The correlation between courses of disease and syndrome types, through statistical analysis, P<0.05, with significant differences; Correlation between sex, age and syndrome type of TCM by statistical analysis, P>0.05, were no significant difference.4. The correlation between sputum smear, CDs+T, CD4+T, CD4+T/CD8+T ratio, IL-2, Th2(IL-4、IL-6、IL-10), TNF-α and syndrome type, through statistical analysis, P>0.05, were no statistical difference. The correlation between CDg+T, IFN-γ and syndrome type, through statistical analysis, P<0.05, with statistical difference.Conclusions1. The Traditional Chinese Medicine Syndrome rules of untreated secondary pulmonary Tuberculosis are as follows:(1) syndrome differentiation as Qi and Yin deficiency:tidal fever in the afternoon, weak and low sound of coughing, anemophobia, thin white sputum, spontaneous perspiration, night sweat, pale, dispiritedness, feeble voice, flushed checks in the afternoon, poor appetite, cough, light pale tongue with teeth marks, less moss, pulse fine.(2)syndrome differentiation as Lung Yin deficiency:cough, expectoration, night sweat, mouth and throat dry, tidal fever in the afternoon, feverish palms and soles, sputum with blood streak a dull pain in the chest, xerosis cutis, sticky sputum, paroxysmal cough, red tongue with less fluid, less moss, thready rapid pulse.(3) syndrome differentiation as Fire excess from Yin deficiency:cough, night sweat, dry pharynx, tidal fever in the afternoon, thirst, flushed checks in the afternoon, Feverish sensation over the five centers, hectic fever, red dry tongue, yellowish thin moss, thready rapid pulse.2. The most common type of syndrome is Lung Yin deficiency, followed by Qi and Yin deficiency, and the last is Fire excess from Yin deficiency.3. Gender, age, sputum smear, CD3+T, CD4+T, CD4+T/CD8+T,1L-2, Th2(IL-4、IL-6、 IL-10),TNF-α index has no impact on the distribution of TCM syndrome types. Course of the disease, CD8+T and IFN-gamma may effect on the distribution of TCM syndrome types.