| Purpose:Through the ERPs detection method, HAMD and HAM A table and the insomnia severity index (ISI) table, this paper observes the efficacy difference among electric acupuncture combined with repetitive Transcranial Magnetic Stimulation (rTMS), rTMS and drug treatment for depressive disorder, and explores that whether electric acupuncture has synergy to rTMS through combining with the clinical observation indicator and analyzing the therapeutic mechanism of electric acupuncture and rTMS on patients with depressive disorder.Methods:90MMD patients were involved in this research and randomly divided into the group of electric acupuncture combined with rTMS, rTMS group and drug treatment group respectively with30patients in each group. In addition, another30normal people were comprised of the control group. Patients from the group of electric acupuncture combined with rTMS were given with the electric acupuncture treatment for2weeks (15d) on the basis of rTMS treatment, and also were regularly and continuously administrated with optical5-SSRI antidepressant drug. The rTMS group patients were only given with the repetitive Transcranial Magnetic Stimulation for2weeks (15d), and the patients from the drug treatment group were administrated with the similar antidepressant drugs. Hamilton’s HAMD and HAMA table with24items, MMN incubation period, P3b value in incubation period, patients" response time and accuracy of target stimulation of the three groups before the treatment, after the2nd weeks since the treatment and at the4th week were evaluated and tested.Results:1. The follow-up results after15days and30days since the treatment showed that:The incubation period of MMN of patients from the group of electric acupuncture combined with rTMS was obviously shortened, which was significantly different with those of the rTMS treatment group (P<0.05):the ISI mean deduction value of patients from group of electric acupuncture combined with rTMS was higher than that of the rTMS group, and there was obvious difference between the two groups (P<0.05).2. After15days since the treatment of electric acupuncture combined with rTMS.HAMD scere was significantly reduced compured w before the treatment, with significant difference (P<0.05), and the obvious effective rate was73.3%. After15days since the treatment of patients from the rTMS group, HAMD score was significantly reduced compared with that before the treatment, and the obvious effective rate was53.3%. The obvious effective rate of the group of electric acupuncture combined with rTMS was significantly higher than that of the rTMS group. There was no significant difference of the reduced integral values between the group of electric acupuncture combined with rTMS and rTMS group (P>0.05). From the follow-up of the two groups30days after the treatment, HAMD score of the group of electric acupuncture combined with rTMS was reduced further, which was significantly different with that before the treatment (P<0.05), and the obvious effective rate was76.7%. The rate of the rTMS group was70.0%, which was lower than that of the group of electric acupuncture combined with rTMS. There was no significant difference on the reduced integral values between the group of electric acupuncture combined with rTMS and the rTMS group (P>0.05). After15-day treatment for the patients of the group of electric acupuncture combined with rTMS, the follow-up visit was conducted30days before the end of the treatment. Compared with the score before treatment, HAMA score was obviously reduced with significant difference (P<0.05). However, upon the above two time points, the HAMA reduced integral values has no obvious difference with the rTMS group (P>0.05).3. From the follow-up visits15days and30days after the treatment of the group of electric acupuncture combined with rTMS and the rTMS group, the response time and accuracy time of target simulation have no significant difference with those before treatment (P>0.05).Conclusions:1. Electric acupuncture combined with repetitive transcranial magnetic stimulation can effectively improve patients" memory and sleep disorders. During the one-month follow-up visit and15days after the treatment, its treatment effect is obviously better than that of rTMS, showing the existed synergy of electric acupuncture on the above clinical symptoms of patients with depressive disorder;2. Electric acupuncture combined with rTMS can significantly alleviate the anxiety and depressive emotion of patients with depressive disorder, and improve their cognitive function, for which there found no obvious synergy produced by electric acupuncture.3. Electric acupuncture combined with rTMS makes no obvious improvements for the damaged attention-implementation function of patients with depressive disorder (this may be correlated with the sample content). |
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