The Pharmaceutical Reasearch Of Qingzi Cataplasm

This paper made a systematic study treatment of traditional Chinese medicinepreparation purpura cleared purple cataplasm. The study includes:1. Extractionprocess;2. Molding process;3. Cataplasm in vitro percutaneous experiment;4.Study of quality standards;5. Stability;6skin allergy test and local irritation test.Orthogonal experiment method is preferably used in the extraction processLithospermum best extraction process: that is10times the amount of solvent95%ethanol extract2times, each time1h, extraction temperature of55°C. Moldingprocess as an indicator of initial tack and hold tack by single factor and orthogonalexperiment to get the the clear purple Papua agent optimal recipe:6%sodiumpolyacrylate,0.29%glycine aluminum,0.29%of citric acid,28.5%glycerol as ahumectant, the results show that the cataplasm check the results obtained by thismethod comply with the relevant provisions. Experimental study of in vitrotransdermal to β，β′-dimethyl acryloyl A Kaning, transmission rate as an indicator,the Franz diffusion cell method for in vitro percutaneous absorption studyinvestigated Azone and propylene glycol are two common penetration enhancersagent Qing purple the cataplasm drug release in vitro effects of the final selection ofthe2%azone as clear purple Papua agent penetration enhancers. TLC was used inthe study of quality standards and specific identification of preparationsLithospermum; HPLC method was used for the preparation-Dimethyl-acryloyl, β’A Kaning content were measured. Qing purple cataplasm stability studies,accelerated testing and long-term stability test results show that the stability of thepreparation. Finally, a skin allergy test and local irritation test results prove that theQing purple cataplasm no obvious skin stimulation, safe and non-toxic.