Study On The Synthetic Process Of Prothioconazole

Pesticides are an important part of modern agriculture. On the one hand, thenew broad-spectrum fungicide triazole thiones have a broad spectrum fungicidal activity, good biological toxicity and ecotoxicity, good effect for prevention disease. O-n the other hand, it can improve of the yield and it is safe for the users, crops and environmental. Prothioconazole has a great potential in triazole fungicide sulfur-ketones. With further study on the synthesis and application of technology, Prothio-conazole has a more broad application prospects in agricultural production of ourcountry. This dissertation is focused on process research synthesis of prothioconazol-e.In the present paper, synthetic methods of prothioconazole were reviewed in d-etail. With the disadvantages and advantages on the synthetic routes, design of a new synthetic process for industrial production. Prothioconazole was synthesized fro-m2-acetylbutyrolactone via chlorination, hydrolysis, decarboxylation, substitution, grignard reaction, nucleophilic addition and electrophilic addition of sulphur powder.Under the optimal condition, the total yield was9.41%based on2-acetylbutyrolactone and the purity was98.79%(Literature8.24%). Meanwhile the problems in eachof the reaction and side reactions were studied and discussed. The synthetic process has some advantages of high yield, simple operation and high purity, and is suita-ble for industrial production. The chemical structures of prothioconazole and intermediates had been characterized by1H-NMR.