The Relationship Between The Resting Heart Rate And Prognosis In Patients With Acute Coronary Syndrome

Objective: Retrospective analysis hospitalization and follow-up data ofpatients with acute coronary syndrome(ACS), investigate the relationship ofadmission and discharge resting heart rate(RHR) with the incidence of majoradverse cardiovascular events (MACE) in patients with acute coronarysyndrome in the era of intervention combined with intensive drug therapy.Provide an evidence for patients with acute coronary syndrome in riskstratification and early intervention.Methods：Continuous record clinical data of931patients with ACS inAffiliated Zhongshan Hospital of Fudan University from January2011toMay2012, and contact by telephone or clinic visit. MACE was defined as thecombined end point of cardiac death, non-fatal myocardial infarction, stroke(fatal or non-fatal) and coronary revascularization [percutaneous coronaryintervention (PCI) or coronary artery bypass graft (CABG)].Results：519(73.1%) with unstable angina and191(26.9%) with acutemyocardial infarction.120(16.7%) patients were hit by MACE after meanfollow-up of19±8months. Compared with the group with an admission RHRless than73beats per min (bpm), there was higher incidence (21.6%vs.12.9%, p<0.01) and risk [hazard ratio (HR)1.594,95%confidence interval(CI)1.105-2.300, p＜0.05] of MACE in group with admission RHR morethan73bpm, and significant differences were revealed with respect to theKaplan-Meier survival curves of the two groups (Log Rank P=0.002). Admission RHR is an independent risk factor for recurrence of MACE (HR1.018,95%CI1.004-1.033, p＜0.05).Conclusion：Patients with admission RHR more than73bpm havehigher risk to have MACE, and was an independent predictor for recurrenceof MACE in patients with ACS.