Study On Relationship Between TCM Syndrome Type Of HBeAg Negative Chronic Hepatitis B And HBsAg Quantification

Objective:To explore the relationship between the TCM syndrome distribution of HBeAg negative chronic hepatitis B patients and quantity of HBsAg,which can provide objective evidence for TCM syndrome differentiation of HBeAg negative chronic hepatitis B and for the Chinese medicine treatment of HBeAg negative chronic hepatitis B and provide theoretical basis of virology.Methods:97patients with HBeAg negative chronic hepatitis B as the object of observation. According to TCM syndrome differentiation standard were divided into "Damp heat syndrome, liver stagnation and spleen deficiency syndrome, liver kidney yin deficiency, blood stasis and spleen kidney yang deficiency syndrome". Serum HBsAg detected by chemiluminescence detection of immune,and the patient’s other object such as HBV DNA, ALT were observed too.The relationship between TCM syndrome and HBsAg titers, HBV DNA,ALT was analysed.Results:97patients including in TCM distribution such as stagnation and spleen deficiency syndrome> damp heat resistance syndrome> liver and kidney syndrome> blood stasis syndrome> spleen deficiency syndrome; HBsAg quantitation of four syndrome mean:liver stagnation and spleen deficiency syndrome>damp heat syndrome>blood stasis syndrome> liver kidney yin deficiency syndrome.There were significant differences among liver kidney yin deficiency syndrome groups and liver stagnation and spleen deficiency syndrome, damp heat resistance syndrome (P<0.01). There were significant differences between blood stasis and stagnation of liver and spleen deficiency syndrome too(P<0.05). While no significant differences among the other groups(P>0.05) was found. ALT value of four syndrome mean: damp heat syndrome>blood stasis syndrome>liver stagnation and spleen deficiency syndrome>liver kidney yin deficiency syndrome. There were significant differences among damp heat syndrome and liver stagnation and spleen deficiency syndrome, liver kidney yin deficiency syndrome(P<0.01). There were significant differences between liver kidney yin deficiency syndrome and liver stagnation and spleen deficiency syndrome(P<0.05).HBV DNA lg value has no significant difference in different syndromes(.P=0.12). HBsAg quantification in different HBV DNA lg value has no significant difference (F=1.33, P= 0.27),but ALT were significantly different(X2=6.705, P=0.035). HBeAb negative or positive patients’HBsAg quantitation, HBV DNA lg value,ALT difference were not statistically significant (P=0.46,0.30,0.27).Conclusion:1.HBeAg-negative chronic hepatitis B patients with TCM distribution as follows: stagnation and spleen deficiency syndrome>damp heat resistance syndrome>liver and kidney syndrome>blood stasis syndrome>spleen deficiency syndrome;2. Four TCM of HBeAg-negative chronic hepatitis B have some relationship with HBsAg quantification;3. HBV DNA level of HBeAg-negative chronic hepatitis B patients and HBsAg quantification is unrelated,but can affect ALT levels;4. HBeAb and HBsAg, HBV DNA, ALT is irrelevant.