The Value Of2-dimensional Speckle Tracking Imaging In Evaluating Heart Failure With Normal Left Ventricular Ejection Fraction

Objective:This study used two-dimensional speckle tracking imaging (2-DSTI) to observe the strain, strain rate, synchronicity of heart failure with normal left ventricular ejection fraction (HFNEF) patients and asymptomatic with left ventricular diastolic dysfunction (LVDD) patients. At the same time, observing the correlation between the2DSTI measured indicators and plasma NT-pro BNP levels. To investigate the value of2DSTI in the diagnosis and evaluation of left ventricular diastolic function, systolic function and myocardial motion synchrony in the HFNEF patients.Methods:Patients with HFNEF23examples, and a control group of asymptomatic with LVDD17examples, recorded the basic information, such as height, weight, determination of the plasma NT-pro BNP level, compared the difference between the two group.At the same time, the echocardiography recorded left atrial diameter, left ventricular end-diastolic diameter, left ventricular ejection fraction, mitral valve blood flow velocity, mitral valve annulus motion velocity. Acquisition apical four-chamber, three-chamber, two-chamber view dynamic two-dimensional image import Qlab8.1software, analyzed of three sections, and global longitudinal strain and strain rate versus time of the curve, recorded left ventricular global and each section systolic strain and the early diastolic strain rate,16,12,6segments standard deviation of time to peak systolic velocity (Ts-SD), the maximal temporal difference of two corresponding segments to systolic velocity(Ts-diff).Using SPSS software analyzed the strain and strain rate, Ts-SD, Ts-diff and the NT-pro BNP correlation;Compared the2DSTI measured indicators difference between the two groupResults:l.The NT-pro BNP level of HFNEF group is higher than asymptomatic with LVDD group, the difference was statistically significant (p<0.05); LogNT-pro BNP and Ea, E/Ea, GLSRe, Ts-SD16were significantly correlated.2.HFNEF patients’global and two-chamber systolic longitudinal strain (GLSs、02-LSs), global and two-chamber, three-chamber, four-chamber early diastolic strain rate (GLSRe,02-LSRe,03-LSRe,04-LSRe) was significantly lower than the asymptomatic with LVDD group, the difference was statistically significance (p<0.05).3.HFNEF group the value of16,12segments’Ts-SD, Ts-diff is bigger, the difference was statistically significant (p<0.05). Ts-SD, Ts-diff and GLSs, GLSRe were significantly correlated.Conclusions:1.2DSTI has significant correlation with the NT-pro BNP level, strain and strain rate is a good indicator in evaluating HFNEF.2. For HFNEF patients, the assessment of left ventricular systolic function by2DSTI is better than of LVEF, The2DSTI can discover the change of left ventricular systolic function more earlier;2DSTI had higher sensitivity to evaluate the diastolic dysfunction’s degree. At the same time it can determine the synchronicity of myocardial activity, provides a new thought of the diagnosis and treatment of HFNEE...