The Discussion Of GOUT’S TCM Syndrome Differentiation And Treatment,and The Development Of A Kind Of Cataplasm

Objective This article try to describe the symptoms of gout artist Analysis of gout history.etiology and pathogenesis. In order to describe the type of gout artist.Determine gout type with traditional Chinese medicine. Combine with the clinical practice of Chinese medicine doctor.We composed expressly for external use of gout.Verify the effect of animal experiments and determine basic components of cataplasm explore the extraction process of Chinese medicine of gout cataplasm.Methods To study TCM syndrome by research reference related literature mainly for external use and explicit the syndrome manifestation during in2000to2013in Domestic medicine journals, periodicals and Chinese Integrative Medicine Journal Full-text Database, China’s outstanding dissertations database, a database of China’s important conference papers. Analysis Statistical data by EXCEL2003. Decide gout syndromes and identified prescription.Based on clinical effectiveness,we made a preliminary study in animal experiments and cataplasm productions. In view of improved reference Coderre TJ Chen rat model,we established gouty arthritis mode. The rats were divided into6groups. After made the a successful gouty arthritis mode five hours ago. Dressing treatment after24hours and48h. Measuring swelling ankle of rats, demonstrate the effectiveness of cataplasm.Extraction experiments were performed to extract the drug by orthogonal experiment. Evaluation of alkaloid content, total alkaloid content and dry extract yield. Determine the optimum extraction of drug extraction process optimization to increase the amount of water, extraction time, herbs particle size factor. Cataplasm matrix detection index with spreadability, drapability, adhesion, cohesion, heat resistance, gels speed.Cataplasm for use in patients with joint pain, skin color, local swelling, local hot flashes, Score recorded for the treatment of acute gouty arthritis clinical efficacy poultice for verification.Results1. Through literature suggests about acute gouty arthritis,syndrome of humid-heat retention. Phlegm-aeeumulation stasis. Stagnaney of heat aeeumulation. Phlegm stasis pathological factors of acute gout syndrome accounted for72.40%; with spleen deficiency based on the proportion of chronic gout was27.6%.2. Poultice prescription alleviate the effect of the rat model of acute gout joint swelling and pain. Chinese medicine acutum high-dose group (Chuanwu10g, Caulis15g, Asarum5g, indica10g, gypsum20g, borneol5g) Compared with western medicine group(P<0.05). Chinese medicine Tripterygium high dose group (Chuanwu10g, Tripterygium15g, Asarum5g, indica10g, gypsum20g, borneol5g) Compared with western medicine group(P<0.05).3. The final optimized solutions of cataplasm preparing:weighed300g Asarum with proportion of the original medicinal prescription, plus six times the amount of water extracted by steam distillation of volatile oil about2.5h. Separation volatile oil use another device storage; aqueous extract was filtered, concentrated and ethanol containing alcohol amounted to65%, standing, filtration, spare; dregs plus5times the amount of65%ethanol extraction1h, filtered, spare. Merge2times filtrate recycle ethanol, concentrated and set aside. Weigh prescription proportion of gypsum1200g, plus the amount of boiling water8times for2h, filtered, spare; dregs six times the amount of water, boiling1h, filter, merge two times filtrate was concentrated and set aside. Mixing the concentrate three times to remove the suspended oil, the precipitate was removed by centrifugation, the extract was concentrated to spare. Weigh proportion prescription borneol300g, grind into a fine powder, dissolved with a small amount of ethanol was added to the extract in;10.2ml the volatile oil was added to the extract, stir, made every extract equivalent to0.55g of crude drug, frozen and set aside.4. Clinical experiments show that the color of the patient’s skin, joint pain, swelling, local hot flashes were1.671,1750,2.563,1.985score. Clarify cataplasm have exact effect for pain, swelling of the joints in patients with acute gouty arthritis.Conclusion After subtraction from Aconitum gout soup base recipe, herbs extract extraction optimized by orthogonal test, extract content was high, and the ratio of stable matrix cataplasm for clinical patients with acute gout have a therapeutic effect, it is worth promotion.