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The Application Value In Of18F-FDG PET/CT Early Detecting The Recurrence Of Nasopharyngeal Carcinoma After Radiotherapy

Posted on:2015-02-15Degree:MasterType:Thesis
Country:ChinaCandidate:Y Y LuFull Text:PDF
GTID:2254330428983715Subject:Department of Otolaryngology Head and Neck Surgery
Abstract/Summary:PDF Full Text Request
Objective To investigate the clinical value of18F-FDG PET/CT in earlydetecting the recurrence of nasopharyngeal carcinoma after radiotherapy.Methods A retrospective analysis of57patients with NPC after radiotherapywith18F-FDG PET/CT and MRI image data，in order to histopathological or clinicalfollow-up data for the standard. Recurrent group has43cases, while non-recurrentgroup with14cases.Results For detecting the recurrence of post-radiation NPC, the sensitivity ofPET/CT and MRI were97.6%and81.4%, respectively; specificity,71.4%and57.1%;accuracy,91.2%and75.4%; positive predictive value (PPV),91.3%and85.4%;negative predictive value （NPV）,90.9%and50%, respectively. The sensitivity,accuracy and NPV of PET/CT are higher than MRI, with significant difference（P<0.05）, while specificityand PPV without significant difference （P>0.05）. Theaverage standard uptaken value (SUV) was7.98±3.29in the recurrent group, while3.31±2.09in the non-recurrent group, with significant difference (P<0.05).Conclusion18F-FDG PET/CT have high accuracy rate and sensitivity in earlydetecting to the recurrence of nasopharyngeal carcinoma after radiotherapy, which canbe considered as a reliable tool of clinical diagnosis.
Keywords/Search Tags:Nasopharyngeal carcinoma, Recurrence, Positron-emissionTomography, Magnetic resonance imaging, Standard uptaken value
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