Blood Pressure Variability And Its Relationship With Cognitive Function In Elderly Patients With Essential Hypertension And Type2Diabetes

ObjectiveTo investigate blood pressure variability of Elder hypertensives with type2diabetes andits relationship with cognitionMethods1. A total of143elderly hypertensives were enrolled and divided into diabetic group (59cases) and non-diabetic group (84cases), and we compared the difference of generalclinical characteristics, biochemical parameters, carotid ultrasound, aneuropsychological Scales and24-hour ambulatory blood pressure (24hABPM)parameters between the two groups of subjects.2. Then the two groups （diabetic group and non-diabetic group）were further dividedinto (Mild cognitive dysfunction,MCI) subgroup （MMSE>26)and normal cognitionsubgroup （MMSE≤26)respectively on the basis of mmse scores,and we analyzed thedifference of the parameters of ABPM between the two subgroups.Results1. compared with the control group，24hSBP、24hPP、dSBP、dPP、nSBP、nPP、24hSSD、dSSD、nSSD、24hSCV、dSCV and nSCV were significantly higher in the diabeticgroup (p<0.05)，however， cognition was lower in the diabetic group. No significantdifference was found in the circadian pattern of blood pressure between the two groups.4.2.24hSSD、dSSD、nSSD、24hSCV、dSCV、nSCV were significantly higher in the MCIsubgroup than normal cognition subgroup in both diabetic and non-diabeticgroups(p<0.05), and they were negatively associated with scores of mmse， thecorrelation coefficient were-0.235、-0.246、-0.341、-0.158、-0.222、-0.238（0.001≤P<0.05）。 Conclusions1.Our study showed that in the elderly with hypertension, the mean systolic bloodpressure and blood pressure variability were both higher in the diabetic group，and thecognition was lower instead.2.Whether or not with diabetes, blood pressure variability were always higher in the MCIsubgroup.3. Blood pressure variability increased in patients with diabetes,and was associated withcognitive decline.