Strong Static Magnetic Field Effect On Cells Mitochondrial Fuction

Cancer is a genetic disease. Benign and malignant tumors are into two categories. Inthe history of modern human medicine, tumor disease has been a threat to human healthand even their lives.Currently, the methods of cancer treatment, many types, mainlychemotherapy and surgery. But sometimes the treatment is ineffective, the patient sufferednot only physical pain, but also the huge expense and post-treatment therapy. Thus, weneed to find a new approach and a new direction to solve these problems. Recent years, agrowing number of researchers study the biological effects of orientation in terms of themagnetic field. In the experimental results of Researchers, we found that tumor cellsproduce a stronger impact than the normal cells; capable of inhibiting the growth of in vivotumor cells or in vitro tumor cells; regulation of apoptosis. So it has great significiance totake advantage of the biological effects of magnetic fields to treat tumors.Permanent magnet magnetic material is the most common and most widely usedmaterial. Basic application has been in the medical field. The basic material as themagnetic field generated by permanent magnets, which produces a magnetic field strengthis stable and can provide a stable environment for the field of tumor cells. In this paper, weuse a strong magnetic anomaly magnetized permanent magnetic actuator avoided, which isdevelped by Shenyang University of Technology, Institute of electromagnetic theory andnew technology developed, National Invention Patent ZL200710011163.Generating a4.5T static magnetic field（SMF）. Select people acute lymphocytic line Jurkat as researchsubjects, to study the biological effects of magnetic fields on tumor cells. Importantintracellular organelles are mitochondria, controling physiological activity of cells.Mitochondria are the central of the cellular respiratory chain and oxidative phosphorylation,also are the important part of apoptosis. We use the SMF to irradiated Jurkat cells, testingchanges of the related components, observing the changes in mitochondrial. Find themechanism in magnetic field on the mitochondrial.Experimental results show that Jurkat cells are irradiated by4.5T SMF for24h,experimental group mitochondrial ultrastructure changes: swelling, crest blurred or even disappear. The structure of mitochondria in control group is nomal, rod-shaped. We cansee: full rules and a clear form, neatly arranged mitochondria.Field irradiation time was1h,8h and24h, intracellular glutathione levels are lower in the experimental group than thecontrol group cells. Field irradiation time was2h,3h,4h,6h, the experimental cells activeoxygen content higher; exposured for8h,12h and24h, intracellular active oxygen levelsare lower in the experimental group than the control group cells. Field irradiation time was2h,3h,4h, the experimental cells adenosine triphosphate content higher; exposured for6h，8h,12h,24h, intracellular adenosine triphosphate levels are lower in the experimentalgroup than the control group cells.We can see from our experimental results that4.5T SMF may have an impact onmitochondrial structure in Jurkat cells, affecting the active oxygen associated withmitochondrial function and adenosine triphosphate, and also the glutathione contentassociated with free radical scavenging.The biological effects of magnetic fields on cellsare related with time. Irradiation time type field, the content of the change is different.