Analysis Of The Relationship Between FGF23and Calcium And Phosphorus Metabolism In Pre-dialysis Patients Of Chronic Kidney Disease

Objective:To explore the levels and associated factors of FGF23in pre-dialysis patients of chronic kidney disease at different stages.Methods：Detected the serum levels of fibroblast growth factor-23(FGF23)and it’s associated factors such as Klotho protein,1,25(OH)2VitD3, intactparathyroid hormone(iPTH), phosphate, calcium and alkalinephosphatase(ALP),as well as collected the clinical information of137CKDpre-dialysis patients and35health controls.Results:The median levels of Serum FGF23in team controls and CKDpatients at stages1-2,3,4and5was15.37pg/ml,15.67pg/ml,22.86pg/ml,37.33pg/ml and63.48pg/ml,respectibely. FGF23begun increased at CKD stage3compared with health group（P<0.05）, also iPTH and ALP increased and1,25(OH)2VitD3decreased begun at CKD stage3compared with health group（P<0.05）, Klotho protein, serum phosphate begun increased and calciumdecreased at CKD stage4compared with health group（P<0.05）.Multiple linearregression analyse demonstrated that estimate glomerular filtrationrate(GFR),serum phosphate,Klotho protein and high density lipoprotein(HDL)were the independent fators affecting FGF23in the total CKD patients. Conclusion:The levels of FGF23changed earlier than serum calcium,phosphate and Klotho protein, it may thus represent a new biomarker for thediagnosis of the disordors of calcium and phosphorus metabolism.eGFR,serumphosphate,Klotho protein and HDL were the independent fators factors affectingFGF23.