Resting State Brain Default Mode Network Changes In Vascular Cognitive, No Dementia: A Resting-state FMRI Study

Objective：To study the resting state changes of brain default mode network (DMN) invascular cognitive impairment, no dementia (VCIND) by Resting state functional magneticresonance imaging(R-fMRI).Methods：The clinical data of14patients with VCIND came from our hospital neurologydepartment outpatient and inpatient between March2012and January2013,who received BloodOxygen Level Dependent on the resting state fMRI(BOLD-fMRI) examination were analyzedretrospectively, and compared with15age-, sex-and educational level-matched healthy subjectswithout cognitive impairment. T1three-dimensional reconstruction images and resting stateBOLD-fMRI images were used to calculate fractional amplitude low-frequency fluctuation ineach grey matter voxel of default mode network and functional connectivity between posteriorcingulum and other brain grey voxels and establish fALFF and FC Within the group brain model,and compare the difference between the fALFF value FC value between the two groups.Result：1. fALFF analysisWithin-group: Widely spread regions of posterior cingulum, adjacent precuneus，inferiorparietal lobule，frontal, occipital and temporal lobes exhibited high fALFF values in both groups.In those areas, posterior cingulum and adjacent precunens showed the highest fALFF values inboth groups (P<0.05).Between-group: Compare to normal controls, VCIND patients showed decreased fALFF inthe posterior cingulate cortex, adjacent precuneus, bilateral rectus, right middle frontal gyrus，right medial superior frontal gyrus and left orbital medial frontal gyrus. In addition, the VCINDpatients also showed increased fALFF in the left temporal gyri and left cerebellum (P<0.05).2. FC analysisWithin-group: Widely spread regions of parietal, frontal, occipital and temporal lobesexhibited high FC values in both groups. In those areas, posterior cingulum and adjacentprecunens showed the highest fALFF values in both groups (P<0.05).Between-group: Compare to normal controls, VCIND patients showed decreased FC in theposterior cingulum, adjacent precuneus, right middle frontal lobe regions and right occipital lobe.In addition, the VCIND patients also showed increased FC in the left superior temporal gyri, theleft middle temporal gyri, the right superior temporal gyri and the left inferior parietallobue(P<0.05). Conclusion:It enabled us to know more about the VCIND pathophysiologic mechanisms of the diseasethrough detecting the default cerebral blood oxygen level changes, which is closely related tocognitive function.in VCIND at a resting state by resting state functional magnetic resonanceimaging, and provided functional image evidence for the clinical diagnosis of VCIND.