The Clinical Research Of Yi Shen Wen Yang Tang Treating The Yang Deficiency Type Of Luteal Phase Deficiency (LPD)

Luteal Phase Deficiency (LPD) refers to the corpus luteum insufficiency whenthe follicle forms the corpus lutein after ovulation. The major meaning refers thecorpus lutein cells in the luteal phase synthesis and secretion of both estrogen andprogesterone, so the endometrium shows irregular ripening with menoxenia, and theconsequence will influence the implantation of the fertilized ovum or result inabortion in early pregnancy phase. The disease belongs to "infertility "、"miscarriage"or "irregular menstruation" in Chinese Medicine. Nowadays, the usual treatment ofWestern Medicine for the disease is hormone therapeutics, the clinical curative effectis not very good, meanwhile, they are certain complications and side effects. Based onthe clinical experiences and the study of literatures of Western and Chinese Medicine,Pro.He regarded "reinforcing kidney and tonifying yang" as the basic principle, andprovided a new therapy for LPD. This research is the first step study about clinicaleffective and therapeutic mechanism in LPD by "YI SHEN WEN YANG TANG".Choose 28 cases of LPD patients belong to the kidney yang deficiency, take thedecoction from the 6th day of high temperature. Observe the index including the basalbody temperature(BBT)、P and related symptoms such as short menstrual cycle、prolonged menstruation or profuse menstruation. All patients receive a course oftreatment of three menstrual cycles.The result show that the effective rate of Yi Shen Wen Yang Tang is 82.1％. Aftertreated with the decoction, fluctuation of BBT in luteal phase was lessened, lutealphase of BBT was prolonged and ascended velocity of BBT after ovulation wasaccelerated. In the group, serum serum P in midluteal phase has been increasedsignificantly. And all the symptoms of the patients have been greatly improved.Owing to the results of clinical research, we can draw the conclusion that Yi ShenWen Yang Tang probably strengthen corpus lutein and promote progesterone secretionthrough regulating the disorderly function of hypothalamic-pituitary-ovarian axis.