Non-small Cell Lung Cancer Prognostic Factors And Different Treatment Options Analysis

Objective①To compare the effect of different adjuvant therapy (chemotherapy or/and radiotherapy) to clinical prognosis of non-small cell lung cancer after surgical operation in population with a large size;②To analyze the factor to effect clinical prognosis of non-small cell lung cancer.Methods In this retrospective study, Approximately1500patients with non-small cell lung cancer who underwent surgical operation in2000-2005were included. All cases were divided into Chemotherapy Group, Radiotherapy Group and Chemotherapy plus Radiotherapy Group, and there were respectively512,495and487cases in each group. All cases underwent surgical operation. Cases in Chemotherapy Group received the first project of chemotherapy (Vinorelbine plus Cisplatin or Carboplatin). Cases in radiotherapy Group received three-dimensional conformal radiation therap. Cases in Chemotherapy plus Radiotherapy Group received the same chemotherapy as Chemotherapy Group and the same radiotherapy as radiotherapy Group. Data were collected by medical record and phone visit, including general data, clinical data, disease-free survival time, allover survival time, and level of tumor biomarkers in serum. Levels of tumor biomarkers in serum were determined by electro-chemistry immunity analytical method in1st year,3rd year and5th year after surgical operation in part of patients. For disease-free survival time, allover survival time, ratios of disease-free survival time and allover survival time were calculated by Kaplan-Meier method, and were compared by Log-Rank methods. Levels of tumor biomarkers in serum were compared by variance test. For influencing factor of clinical prognosis, Single-factor analysis was used Log-Rank methods and multi-factor analysis was used Cox model.Results①Disease-free survival time and allover survival time in Chemotherapy Group and Radiotherapy Group were not significant different (P>0.05).②Disease-free survival time and allover survival time in Chemotherapy Group and Radiotherapy Group were significant different from those in Chemotherapy plus Radiotherapy Group (P<0.01).③Levels of SCC and ProGRP in serum were not significantly different in Chemotherapy Group, Radiotherapy Group and Chemotherapy plus Radiotherapy (P>0.05). Levels of NSE, CYFRA21-1, CEA and CA242in serum in Chemotherapy Group and Radiotherapy Group were significantly different from those in Chemotherapy plus Radiotherapy (P<0.05or P<0.01).④Gender, age, operation methods didn’t significantly affect disease-free survival time and allover survival time in statistic (P>0.05), but KPS, neoplasm stage and pathological types significantly affected disease-free survival time and allover survival time in statistic (P<0.05or P<0.01). Conclusion①Chemotherapy and radiotherapy have the similar effects on the clinical prognosis of non-small cell lung cancer after surgical operation.②Chemotherapy and radiotherapy have the better effects on the clinical prognosis of non-small cell lung cancer after surgical operation than chemotherapy plus radiotherapy.③Chemotherapy, radiotherapy and chemotherapy plus radiotherapy have the similar effects on Levels of SCC and ProGRP in serum, and chemotherapy or radiotherapy can induced lower levels of NSE, CYFRA21-1, CEA and CA242in serum than chemotherapy plus radiotherapy.④In therapy of Chemotherapy, radiotherapy and chemotherapy plus radiotherapy,Gender, age, operation methods have no affect on clinical prognosis, but KPS, neoplasm stage and pathological types have significant effect on clinical prognosis.