Both Panax Chemical Constituents Of Medicinal Plants And Biological Activity

China is one of the most rich countries with medicinal plant resources, and Yunnan is the plant kingdom of China.The modernization of Traditional Chinese Medicine (TCM) is based on the research of the sustainable development of medicinal plants resources. Ginseng is a rich variety of valuable medicinal plants This study on phytochemical investigation and pharmacological activities of Ginseng medicinal plants will provide strong support for promotion of the enlarged using and sustainable development of Ginseng medicinal plants by means of modern scientific technology.Ginseng (Panax1.) is the earliest established Araliaceae genera in Systema Naturae by Linnaeus in1735. In recent30years, scholars at home and abroad has researched the genus Panax ginseng Combined with multi-subjectssuch as planting, classification, pharmacology, chemistry, molecular and microbial. Our country has abundant ginseng plant resources. Different plant groups of Panax contain their own respectively characteristic chemical compositions.because of the characteristics of the highest effective component content, diversity of the molecular and widely significant pharmacological activities, it has become the most potential for development and utilization of taxa. This thesis elaborated the chemical constituents of two traditional Chinese medicines:Panax japonicus and processed notoginseng. By various separation materials and techniques,23compounds were isolated. Their structures were elucidated on the basis of detailed spectroscopic analysis and chemical methods. According to the literature and its hypoglycemic effect, the most compounds were tested for activity increasing insulin sensitivity. Three of them show good biological activities in this area.Chapter1. The Chemical Constituents and Antitumor Activities of Panax japonicus. P. japonicus C. A. Meyer (Araliaceae).The rhizome of this plant has long been known as an oriental traditional plant drug in China, Korea, Japan and Europe. In China, the rhizome of this herb has been recorded in the Chinese Pharmacopoeia and used tonourishing and strong, circulation to remove stasis, strengthen the immune system, clear heat, transform phlegm, diminish inflammation, as well as for treatment of lifestyle-related diseases such as high-fat diet-induced obesity and alcohol-induced gastric ulcer. Previously, a number of oleanane-type triterpene glycosides were reported from the title plant. As part of our continuing research on chemical constituents of Chinese Traditional Medicine, a detailed phytochemical investigation on the rhizome of Panax japonicus C.A. Meyer collected in Gaoligong Mountain in Yunnna, China, was carried out, which led to the isolation of13known compounds.Chapter2. Notoginseng, the root of Panax notoginseng (Burk.) F. H. Chen (Araliaceae), is a traditional Chinese medicine, one of the most famous of genuine medicinal materials in Yunnan,which is used both in raw and processed forms due to their different pharmacological activities. Generally thinks raw notoginseng to stop bleeding and remove stasis, invigorate the circulation of detumescence and analgesic effect; And processed forms to invigorating qi and enriching the blood.Detailed chemical investigation on the methanol extacts of steamed notoginseng led to the isolation of17compounds, of which9compounds were identified.most of the types of these compounds are dammarane saponins.Chapter3. Combined with researching work of the graduation project, This paper summarizes recent advances in the research progress of saponins composition and pharmacological activities of Panax japonicus and notoginseng. Aims to providing reference for its further research, development and utilization.