Orthogonal Experimental Study Design (detoxification Group Section) Prescription Optimized For "UC Party" To

Purpose：Through orthogonal experiment, to collapse and qingrejiedu groups of drugs wereanalyzed, and concluded that the role of primary and secondary, and drug interactions ofcollocation, so as to deduce the best drug compatibility.Material and method：This experiment according to the orthogonal design table, SD rats asexperimental object, USES three nitric acid (TNBS) concentrate and anhydrousethanol to build animal model of ulcerative colitis. Observation group afterthe treatment in rats colon on the colon mucosa and its pathological changes,analyze my hospital preparations "collapse" party "group qingrejiedu, primaryand secondary of each drug and the drug interactions of collocation. To deducethe formula the best drug compatibility，Optimizing the formula.Results：On the colon mucosa:1、 null columns R is negative, then separate applications yiqi spleen andpromoting blood circulation to remove blood stasis drugs increase theprogress of the disease. Respectively after join the heat-clearing anddetoxifying drugs, cortex phellodendri, radix trichosanthis, B On the colonmucosa only D treatment effect, the effect is greater than the cortexphellodendri and radix trichosanthis treatment. A reed root rhizoma coptidishu, C, E has not been bitter ginseng treatment effect.2、 In interaction of two drugs, cortex phellodendri and radix trichosanthisand D B on the colon mucosa A rhizoma coptidis hu and E bitter ginseng, rhizomacoptidis hu A and cortex phellodendri and radix trichosanthis and D B E bitterginseng, rehmannia root, cortex phellodendri and C B A rhizoma coptidis huand D cortex phellodendri and radix trichosanthis and B E sophora therapeutic, cortex phellodendri and radix trichosanthis and D and B A rhizoma coptidishu and E sophora> A rhizoma coptidis hu and cortex phellodendri and radixtrichosanthis and D B E sophora reed root cortex phellodendri and C> B=A rhizoma coptidis hu and D cortex phellodendri and radix trichosanthis andB E sophora therapy effect. And A reed rhizome, rhizoma coptidis hu to CC reed rhizome rehmannia root, radix trichosanthis, C and D and E has notbeen bitter ginseng treatment effect.Pathologically:1、 null columns R is negative, then separate applications yiqi spleen andpromoting blood circulation to remove blood stasis drugs increase theprogress of the disease. Respectively after join the heat-clearing anddetoxifying drugs, reed root, radix trichosanthis, D, B, C in pathologycortex phellodendri therapeutic, radix trichosanthis phragmites communisand C=D> B the therapeutical effect of cortex phellodendri. A rhizomacoptidis hu, E has not been bitter ginseng treatment effect.2、 In the interaction of the two drugs, cortex phellodendri and radixtrichosanthis D B in pathology and A rhizoma coptidis hu and E bitter ginseng,rhizoma coptidis hu A and C reed root treatment. And A rhizoma coptidis huand E sophora> A rhizoma coptidis hu to C the therapeutic role of phragmitescommunis. Other combinations of interaction are in contrast to the therapyeffect.Conclusion：First: in the unit in drug treatment, cortex phellodendri B D radixtrichosanthis consistent either on the colon mucosa or in pathology, andtreatment effect is remarkable, the effect is more better than B, cortexphellodendri and radix trichosanthis D treatment. And C phragmites communis onthe colon mucosa and on the pathological results of contradictions, A rhizomacoptidis hu E bitter and not whether therapeutic dosage, with matching method,need to be further discussed. Second: interaction, cortex phellodendri and radix trichosanthis and D BA rhizoma coptidis hu and E sophora compatibility on the colon mucosa andpathological results, qingrejiedu group D C reed rhizome, the lack of treatmenteffect significantly, says more about problems of phragmites communis incollapse and party C.In a word, in qingrejiedu group of cortex phellodendri, radix trichosanthisin crushing and D party B is indispensable, in the whole collapse and whetherother drugs can have treatment effect, to further study.