Clinical Study Of Diarrhea-predominant Irritable Bowel Syndrome (liver Spleen Syndrome) Treatment Shuganjianpi Law

Objective:To observe the clinical efficacy and safety of the method of soothing the liver and invigorating the spleen (sijunzitang&tongxieyaofang) in treating diarrhea-predominant irritable bowel syndrome (liver depression and spleen deficiency syndrome).Methods:eighty cases of diarrhea-predominant irritable bowel syndrome (liver depression and spleen deficiency syndrome) patients were randomly divided into two group, treatment group(n=40, treated with sijunzitang&tongxieyaofang), control group(n=40, treated with The Tong-xie-ning particles), course of treatment is four weeks. Then the two group’s indicators of total symptom score and the clinical symptom score, adverse reactions were observed and compared before and after treatment, using SPSS17.0statistical software to evaluate the clinical efficacy and follow up the recurrence.Result:1、The efficacy analysis:The treatment group, eight cases were cured, sixteen cases were markedly effective, eleven cases were effective, five cases were invalid, the total effective rate was87.5%; the control group, six cases were cured, fifteen cases were markedly effective, twelve cases were effective, seven cases were invalid, the total effective rate82.5%, the treatment group’s total total effective rate is higher than that the control group’s. However, after statistical analysis, the total effective rate of the treatment group compared with the control group was no significant difference (P>0.05).2、Efficacy analysis of clinical symptoms:The total score of the clinical symptoms of the two groups of patients were significantly improved after treatment (P<0.01). But the treatment group was better than the control group in improving the total score of the clinical symptoms (P<0.05). Some symptoms of the treatment group could be more significantly improved than the control group (P<0.05), such as the degree of abdominal pain or discomfort, number of episodes of abdominal pain or discomfort, fullness in chest, hypochondrium and lower abdomen, Diarrhea aggravate when emotional stress or depression, eructation, preference for sighing, fatigue. There was no significant difference between the two groups in improving stool texture and defecation frequency.3、Security:The two groups of patients did not appear the phenomenon of allergies and intolerances during the treatment, and there were no significant toxic side effects.Conclusion:Stagnation of liver qi and spleen deficiency is the key of the pathogenesis of diarrhea-predominant irritable bowel syndrome (IBS-D), treating diarrhea-predominant irritable bowel syndrome (liver depression and spleen deficiency syndrome) by the method of soothing the liver and invigorating the spleen is safe and effective.