Alzheimer Disease Syndrome Factor Features

Objective:To investigate Chinese medicine syndrome elements of Alzheimer’s disease (AD),and it’s influence on the morbidity of AD, in order to provide scientific evidences for treatment based on syndrome differentiation of AD.Methods:The172subjects were from patients of Dongzhimen hospital and residents of surrounding communities (age between45and85years old)duiring May2012to December2013. Based on their neuro-psychological assessments,27of them were diagnosed with AD in using National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA) criteria,75of them were diagnosed with amnestic mild cognitive impairment (aMCI) in using criteria of aMCI reported by Petersen,70of them were normal cognition(NC). And then Chinese medicine syndrome elements were concluded on those subjects in us ing AD syndrome elements scale(AD-PES-11). SPSS19.0was used for statistical analysis.Results:1. There were significantly difference on ages and years of educationa among the three groups(P=000). The age of AD group was higher than that in NC group and aMCI group(P=0.000). The years of education of AD group was lower than those in NC group and aMCI group(P were respectively0.000,0.016).2. The scores of blood deficiency, marrow deficiency and blood stasis were statistically different among the three groups (P=0.026,0.002,0.002). The scores of blood deficiency in aMCI group2.93±2.460was higher than NC groupl.91±2.291(P=0.008). The scores of marrow deficiency in AD group6.13±5.709was higher than NC group2.41±3.181(P=0.001) and aMCI group3.36±3.621(P=0.028).The scores of blood stasis in aMCI group3.67±3.966and AD group5.07±4.571were higher than NC group2.11±3.352(P=0.011,0.001).3. The primary syndrome elements in AD group were kidney def iciency(48.15%), turbid phlegm(48.15%)and blood stasis(40.74%). The primary syndrome elements in aMCI group were kidney def iciency (41.33%),hyperactivity of yang(38.67%), and qi deficiency(30.67%).In NC group they were hyperactivity of yang(37.14%), qi deficiency(31.43%)and turbid phlegm(27.14%). The percents of syndrome elements of kidney deficiency, marrow deficiency and blood stasis were respectively different (P<0.05). The percents of kidney deficiency41.33%in aMCI group and48.15%in AD group were higher than NC group22.86%(P were respectively0.018,0.015).The percent of marrow deficiency in AD group37.04%was higher than NC group8.57%(P=0.001)and aMCI group14.67%(P=0.014). The percents of blood stasis29.33%in aMCI group and40.74%in AD group were higher than12.86%in NC group (P were respectively0.016,0.002). In NC group the major syndrome element was single, while in aMCI and AD group,multiple syndromes paly the primary role (P<0.01).4. Kidney deficiency and blood stasis may be the risk factors of the onset of aMCI (P=0.017,0.008; B=0.960,1.248). Marrow deficiency and blood stasis may be the risk factors of the onset of AD(PH).017,0.023; B=1.747,1.409). Kidney deficiency and blood stasis may be the risk factors of the onset of cognitive impairment (P=0.015,0.004; B=0.920,1.263).Conclusion:1. The increase of age and the lack of education is risk factors for the onset of aMCI and AD.2. The primary syndrome elements of cognitive impairment are kidney deficiency and blood stasis. The primary syndrome elements of AD is marrow deficiency and it is worse than normal cognition. The more complicated the syndrome elements are, the more serious congnitive functions become.3. Kidney deficiency and blood stasis may be the risk factors of the onset of aMCI. Marrow deficiency and blood stasis may be the risk factors of the onset of AD. Kidney deficiency and blood stasis may be the risk factors of the onset of cognitive impairment.