Sinomenine Ethosomes Liposome Hydrogel Plasters And Transdermal Permeation Behavior Of Preparation

Rheumatoid arthritis is a great danger of common diseases can cause severe joint deformity, disability, etc. Sinomenine (Sinomenine HC1, SIN-HCl) is an effective drug loaded Pharmacopoeia rheumatoid arthritis treatment,clinical dosage forms mostly is oral formulations and injections,but the biggest drawback is the short half-time,large amount of drug to patient, low bioavailability. If Sinomenine-HCl was prepared part directly percutaneous,you can prepared a constant steady blood levels to solve its short half-life,need frequent dosing short comings,safety and easy to use.However, the low of through cumulative is a bottleneck of general percutaneous administration preparations and finding the way of drug release is a focus,it cumulative through large,stable the drug release and good clinical adaptability in percutaneous studies, so this article will combine ethosome with hydrogel paste.Ethosomes is a special liposome containing a20%-50%of small molecular alcohols,easier to make the drug into the stratum corneum of human skin or the lipid layer,thus the efficiency of percutaneous absorption is improved,it is suitable for biological half-time short,low oral bioavailability medicine percutaneous release.Hydrogel paste(original name cataplsm) good skin compatibility and large of drug loading volume,the cumulative through is larger than common of transdermal administration.In view of this paper will prepared Sinomenine-hc1ethosomes and added it to hydrogel paste,in order to obtain a better release characteristics in percutaneous.Injection method were used prepared Sinomenine-HCL ethosomes and film dispersion prepared Sinomenine-HCL liposomes. on the basis of single experiment factor,encapsulation efficiency is a Indicators,using star point response surface methodology optimize their prescription,and the prescription was tested and quality evaluated.Using tack (T), gel strength (P) as the marker, the basis of single factor test,using star point response surface methodology formulate optimization the matrix of hydrogel plasters,optimum prescription:0.30%EDTA-2Na,0.2%aluminum glycinate,6.00%sodium polyacrylate,28.00%glycerol,1.50%K-90,0.20%tartaric acid,Storage temperature was30℃.And containing1%Sinomenine-HCL ethosomes hydrogel plasters was preparated.Vitro Transdermal study using Franz diffusion cell,compare Sinomenine-HCL ethosomes hydrogel plasters and Sinomenine-HCL liposome hydrogel plasters in via transdermal cumulative.The results showed that Sinomenine-HCL ethosomes hydrogel plasters is greater than Sinomenine-HCL liposome hydrogel plasters in via transdermal cumulative.Studying herbal compound Effects on hydrogel plasters matrix and its in vitro release behavior.The results showed that hydrogel plasters matrix impacted by medicine extract significantly,eucalyptus oil as penetration enhancers is better than without penetration enhancers in vitro through group.In summary,Sinomenine-HCI ethosomes hydrogel plasters release characteristics is better in this study,easy to use, not only solved sinomenine short half-time of significant deficiencies in treating rheumatoid arthritis but also the problem of low cumulative permeation amount was solvedin common transdermal formulations.For treatment of rheumatoid arthritis has created a good preparation.