Expression From EMG Change And Related Immune Substances Investigate The Relationship Between The Lung And Large Intestine List

As one of the important part of the Viscera Manifestation theory, the theory of "The exterior-interior relationship between the lung and the large intestine" has profound theoretical source. It was first in huangdi neijing, and recorded in a lot of medical books in all ages. In china for several thousand years, the theory is su-mmarized, refined, generalized and enriched incessantly. For thousands of years, this theory has been effectively guides the theory development of traditional Chin-ese medicine and clinical practice. With the development of immunology, molecu-lar biology and cell biology, the theory of "The exterior-interior relationship betw-een the lung and the large intestine" has been studied increasingly deeply, not only has obtained certain achievement on the experimental study, but also be more wid-ely in clinical applications.1ObjectiveThis article aims to study the theoretical basis from the medical literature, analyze of lung, colon and their interlinkages from the micro-level by experimen-tal,to provide up-to-date support for the theory of "The exterior-interior relation-ship between the lung and the large intestine" rich the basic content of the theory, and provide new ideas and methods for state of viscera and theory of the basic the-ory of traditional Chinese medicine.2Method2.1Review and analysis of literatureSummarize the origin,theory of traditional Chinese medicine and modern clinical and experimental research of the theory of "The exterior-interior relationship between the lung and the large intestine" by literature study and logical analysis.2.2Experimental research2.2.1To study the nerve-endocrine substances in lung and intestine:We made model of physiological group, hypoxia group, hyperoxia group, diet restriction group and water restriction group, then took lung, jejunum, ileum and colon.Observed the electromyography changes.2.2.2To study the nerve-endocrine substances in lung and intestine:We made model of physiological group, hypoxia group, hyperoxia group, diet restriction group and water restriction group, then took heart, liver, spleen, lung, kidney, stomach, jejunum, ileum, colon, rectum and bladder.Observed related immune substances.2.2.3To study the nerve-endocrine substances in lung and intestine:We made model of physiological group, hypoxia group, hyperoxia group, diet restriction group and water restriction group, then took lung, jejunum, ileum and colon.Observed LPS signaling pathways.3Result3.1Compared with normal group, the center of the high frequency and the ratio of high and low frequency of lung, jejunum, ileum and colon in various groups were statistically significant. When the high frequency and the ratio of high and low frequency of rats’lung fell in groups of hypoxia and hyperoxia, those decreased in various intestinal segments. When the high frequency and the ratio of high and low frequency of rats’various intestinal segments fell in groups of diet restriction and water restriction, those decreased in lung,3.2Compared with normal group, PGE2levels of rats’lung, jejunum, ileum, colon, spleen and liver increased in various groups. And the changes of PGE2expression of the lung were more close to various intestinal segments.3.3Compared with normal group, content of TLR4of rats’lung and jejunum were statistically significant in various groups. When TLR4contents of rats’lung of in groups of hypoxia and hyperoxia increase, those incresse in jejunum. When TLR4contents of rats’jejunum of in groups of diet restriction and water restriction increase, those increase in lung.4Conclusion4.1Lung and large intestin have certain stability on the pathological changes of electromyography. Lung have correlation with colon in physiology.4.2There is immune correlation between lung and large intestin. Lung and large intestin have common immune material base. PGE2is probably the commen immune substance of the lung and large intestin.4.3Lung and large intestine are related in the signal transduction of LPS receptor TLR4. Lung and large intestine have correlation in LPS signal pathway.