Synergistic Catalysis Of [3 + 2] Reaction Of Metals With Organic Small Molecules

With people living standard rise, people for their own health is becoming more andmore attention, also understand the importance of the drug for us, of course，thedemand for drugs is also more and more, at this time，the drug research anddevelopment also have higher requirements, we hope that can use simple and economicmethod to develop a variety of important drugs, and five membered ring of chiralcompounds is an important structure in drug synthesis, there are a lot of research in theexploration and development of various synthesis methods of five membered ringcompounds and try many different substrates and different catalysts, in order to wehave more methods to choose in drug synthesis method，although there have beenmany research reports about five membered ring compounds synthesis method，but inthis paper，we explore novel catalytic synthesis of chiral ifve membered ringcompounds.Actually metals and organic small molecular catalysts respectively have a lot ofapplications in many areas, they all have their own advantages, and metal catalysts alsohad the very big progress in catalysis and synthesis five membered ring compounds,especially in the catalytic [3+2] reaction that three ring compounds as reactants forsynthesis of five membered ring compounds，and metal catalysts have a lots uses, butsmall molecular catalysts without catalytic reactions of this type, so this article mainlystudies how to apply metal catalyst and organic small molecules to the[3+2] reactionthat three ring compounds as reactants, at the same time, and synthesis chiral fivemembered ring compounds, and let small molecules control the end product of chiral.In this paper, mainly involve two catalysts coordination catalysis the [3+2] reactionthat three ring compounds as reactants, reactants are mainly different D-A ternary ringand different unsaturated aldehyde, we assume that the metal catalysts to open ring,chiral organic small molecular catalysts to combine unsaturated aldehyde, under theconcerted catalysis, the resulting generate chiral five membered ring compounds,experimental results show that the metal and organic molecules catalyst can besynergistic catalytic [3+2] reaction that three ring compounds as reactants, and the small molecule catalyst successful control ifve membered ring compounds of chiral.